Bobak Moazzami1, Keivan Majidzadeh-A2, Arash Dooghaie-Moghadam1, Pegah Eslami3, Niloofar Razavi-Khorasani1, Shahrokh Iravani2, Alireza Khoshdel2, Farhad Shahi1, Habibolah Dashti1, Azim Mehrvar4, Mohssen Nassiri Toosi5. 1. Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2. Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran. 3. Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran. ltrc.tehran@gmail.com. 5. Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran. nasirito@sina.tums.ac.ir.
Abstract
BACKGROUND: Cholangiocarcinoma (CCA) is the second most frequent primary liver tumor and defined as the heterogeneous group of tumors derived from cells in the biliary tree. METHODS AND RESULTS: Based on the anatomical locations (intrahepatic, perihilar, and distal), there are various approaches to the diagnosis and treatment of CCA. Imaging modalities, staging classifications, understandings around natural behavior of CCA, and therapeutic strategies have had remarkable progress in recent years. CONCLUSIONS: This article reviews and discusses the epidemiology, clinical presentation, diagnosis, and treatment modalities of CCA; determines the appropriate inclusion and exclusion criteria for liver transplantation (LT); and defines the risk of disease progression for patients in the waiting list of LT.
BACKGROUND:Cholangiocarcinoma (CCA) is the second most frequent primary liver tumor and defined as the heterogeneous group of tumors derived from cells in the biliary tree. METHODS AND RESULTS: Based on the anatomical locations (intrahepatic, perihilar, and distal), there are various approaches to the diagnosis and treatment of CCA. Imaging modalities, staging classifications, understandings around natural behavior of CCA, and therapeutic strategies have had remarkable progress in recent years. CONCLUSIONS: This article reviews and discusses the epidemiology, clinical presentation, diagnosis, and treatment modalities of CCA; determines the appropriate inclusion and exclusion criteria for liver transplantation (LT); and defines the risk of disease progression for patients in the waiting list of LT.
Authors: Christoph Roderburg; Tobias Essing; Linde Kehmann; Sarah Krieg; Simon Labuhn; Jennis Kandler; Tom Luedde; Sven H Loosen Journal: Cancers (Basel) Date: 2022-08-21 Impact factor: 6.575