Shawn M Hercules1,2, Jevon C Hercules3, Amna Ansari1, Stephanie A J Date2,4, Desiree H A Skeete2,4,5, Suzanne P Smith Connell4,6, Gregory R Pond7,8, Juliet M Daniel1,2. 1. Department of Biology, McMaster University, Hamilton, Ontario, Canada. 2. African Caribbean Cancer Consortium, Philadelphia, Pennsylvania. 3. Department of Mathematics, University of the West Indies at Mona, Kingston, Jamaica. 4. Faculty of Medical Sciences, University of the West Indies at Cave Hill, Bridgetown, Barbados. 5. Department of Pathology, Queen Elizabeth Hospital, Bridgetown, Barbados. 6. Department of Radiation Oncology, Queen Elizabeth Hospital, Bridgetown, Barbados. 7. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. 8. Department of Oncology, McMaster University, Hamilton, Ontario, Canada.
Abstract
BACKGROUND: Women of African ancestry (WAA) are disproportionately affected by triple-negative breast cancer (TNBC), which remains one of the most clinically challenging breast cancer (BCa) subtypes. This study investigated the prevalence of TNBC and epidemiological trends for BCa in Barbados, a Caribbean island with a high percentage of African ancestry. METHODS: Pathology reports for all BCa cases between 2007 and 2016 were collected from the sole hospital in Barbados and reviewed. The clinicopathological data collected included age, tumor grade, lymph node status, and hormone receptor status as determined by immunohistochemistry. BCa data for non-Hispanic white (NHW) and non-Hispanic black (NHB) American populations were accessed from the Surveillance, Epidemiology, and End Results database. RESULTS: There were 1997 BCa cases in Barbados between 2007 and 2016 for an estimated incidence rate of 135.1 per 100,000 women in Barbados (standardized to the US population, where the standardized incidence rates for NHBs and NHWs were 141.4 and 152.6 per 100,000, respectively). Age-specific incidence rates in Barbados for this period were consistently higher in younger age groups (15-59 years) in comparison with NHWs and NHBs. Between 2010 and 2016 in Barbados, a TNBC prevalence of 25% was observed, whereas TNBC prevalences of 21% and 10% were observed in NHBs and NHWs, respectively. CONCLUSIONS: The BCa incidence was higher in younger Barbadian women than NHWs and NHBs, and the TNBC prevalence was ~2.5 times higher than the prevalence in NHWs. This hints at a possible genetic predisposition and other socioeconomic factors that could explain the high TNBC prevalence and aggressive clinical course in WAA globally.
BACKGROUND:Women of African ancestry (WAA) are disproportionately affected by triple-negative breast cancer (TNBC), which remains one of the most clinically challenging breast cancer (BCa) subtypes. This study investigated the prevalence of TNBC and epidemiological trends for BCa in Barbados, a Caribbean island with a high percentage of African ancestry. METHODS: Pathology reports for all BCa cases between 2007 and 2016 were collected from the sole hospital in Barbados and reviewed. The clinicopathological data collected included age, tumor grade, lymph node status, and hormone receptor status as determined by immunohistochemistry. BCa data for non-Hispanic white (NHW) and non-Hispanic black (NHB) American populations were accessed from the Surveillance, Epidemiology, and End Results database. RESULTS: There were 1997 BCa cases in Barbados between 2007 and 2016 for an estimated incidence rate of 135.1 per 100,000 women in Barbados (standardized to the US population, where the standardized incidence rates for NHBs and NHWs were 141.4 and 152.6 per 100,000, respectively). Age-specific incidence rates in Barbados for this period were consistently higher in younger age groups (15-59 years) in comparison with NHWs and NHBs. Between 2010 and 2016 in Barbados, a TNBC prevalence of 25% was observed, whereas TNBC prevalences of 21% and 10% were observed in NHBs and NHWs, respectively. CONCLUSIONS: The BCa incidence was higher in younger Barbadian women than NHWs and NHBs, and the TNBC prevalence was ~2.5 times higher than the prevalence in NHWs. This hints at a possible genetic predisposition and other socioeconomic factors that could explain the high TNBC prevalence and aggressive clinical course in WAA globally.
Authors: Shawn M Hercules; Meena Alnajar; Chen Chen; Stefan M Mladjenovic; Bolade Ajarat Shipeolu; Olga Perkovic; Greg R Pond; Lawrence Mbuagbaw; Kim Rm Blenman; Juliet M Daniel Journal: BMJ Open Date: 2022-05-27 Impact factor: 3.006
Authors: Sophia H L George; Talia Donenberg; Cheryl Alexis; Vincent DeGennaro; Hedda Dyer; Sook Yin; Jameel Ali; Raleigh Butler; Sheray N Chin; DuVaughn Curling; Dwight Lowe; John Lunn; Theodore Turnquest; Gilian Wharfe; Danielle Cerbon; Priscila Barreto-Coelho; Matthew P Schlumbrecht; Mohammad R Akbari; Steven A Narod; Judith E Hurley Journal: JAMA Netw Open Date: 2021-03-01
Authors: Shawn M Hercules; Xiyu Liu; Blessing B I Bassey-Archibong; Desiree H A Skeete; Suzanne Smith Connell; Adetola Daramola; Adekunbiola A Banjo; Godwin Ebughe; Thomas Agan; Ima-Obong Ekanem; Joe Udosen; Christopher Obiorah; Aaron C Ojule; Michael A Misauno; Ayuba M Dauda; Ejike C Egbujo; Jevon C Hercules; Amna Ansari; Ian Brain; Christine MacColl; Yili Xu; Yuxin Jin; Sharon Chang; John D Carpten; André Bédard; Greg R Pond; Kim R M Blenman; Zarko Manojlovic; Juliet M Daniel Journal: Cancer Causes Control Date: 2022-04-06 Impact factor: 2.532