| Literature DB >> 3215434 |
Y Tsukamoto1, S Nakazawa, K Segawa, H Goto, A Fukui, K Takano, S Hase, T Arisawa, T Osada, Y Kawabe.
Abstract
The anti-ulcer effect of NC-1300, a new proton pump inhibitor, and its effect on gastric mucosal blood flow were studied in rats. Acute gastric mucosal lesions were induced by the subcutaneous administration of serotonin, 20 mg/kg. Using the electrolytically generated hydrogen gas clearance technique, it was determined that such gastric ulceration resulted mainly from a decrease in gastric mucosal blood flow. These lesions could be inhibited to a statistically significant extent by the intravenous administration of NC-1300, 20 mg/kg, which markedly inhibited gastric acid secretion. However, the serotonin-induced decrease in gastric mucosal blood flow could not be prevented by pretreatment with 20 mg/kg of NC-1300. It was concluded that protection against serotonin-induced gastric ulceration can be achieved by markedly inhibiting gastric acid secretion.Entities:
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Year: 1988 PMID： 3215434 DOI： 10.1007/bf02779480
Source DB: PubMed Journal: Gastroenterol Jpn ISSN： 0435-1339