| Literature DB >> 32152477 |
Penghui Zhang1,2, Di Gao3, Keli An1, Qi Shen3, Chen Wang3, Yuchao Zhang3, Xiaoshu Pan2, Xigao Chen2, Yifan Lyv2,4,5, Cheng Cui2,4,6, Tingxizi Liang3, Xiaoman Duan1, Jie Liu1, Tielin Yang1, Xiaoxiao Hu6, Jun-Jie Zhu7, Feng Xu8, Weihong Tan9,10,11.
Abstract
Stimuli-responsive biomaterials that contain logic gates hold great potential for detecting and responding to pathological markers as part of clinical therapies. However, a major barrier is the lack of a generalized system that can be used to easily assemble different ligand-responsive units to form programmable nanodevices for advanced biocomputation. Here we develop a programmable polymer library by including responsive units in building blocks with similar structure and reactivity. Using these polymers, we have developed a series of smart nanocarriers with hierarchical structures containing logic gates linked to self-immolative motifs. Designed with disease biomarkers as inputs, our logic devices showed site-specific release of multiple therapeutics (including kinase inhibitors, drugs and short interfering RNA) in vitro and in vivo. We expect that this 'plug and play' platform will be expanded towards smart biomaterial engineering for therapeutic delivery, precision medicine, tissue engineering and stem cell therapy.Entities:
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Year: 2020 PMID： 32152477 DOI： 10.1038/s41557-020-0426-3
Source DB: PubMed Journal: Nat Chem ISSN： 1755-4330 Impact factor: 24.427