Literature DB >> 32152078

ARGONAUT II Study of the In Vitro Activity of Plazomicin against Carbapenemase-Producing Klebsiella pneumoniae.

Michael R Jacobs1,2, Caryn E Good3,2, Andrea M Hujer4,5, Ayman M Abdelhamed3,2, Daniel D Rhoads3,2, Kristine M Hujer4,5, Susan D Rudin4,5, T Nicholas Domitrovic4,5, Lynn E Connolly6, Kevin M Krause6, Robin Patel7, Cesar A Arias8,9,10,11, Barry N Kreiswirth12, Laura J Rojas4,5, Roshan D'Souza13, Richard C White13, Lauren M Brinkac13, Kevin Nguyen13, Indresh Singh13, Derrick E Fouts13, David van Duin14, Robert A Bonomo15,5,16,17,18,19,20.   

Abstract

Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA methyltransferases in all except 1 isolate.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  Klebsiellazzm321990; antibiotic resistance; carbapenemase; plazomicin

Mesh：

Substances：

Year:  2020        PMID： 32152078      PMCID： PMC7179617          DOI： 10.1128/AAC.00012-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Activity of plazomicin compared with other aminoglycosides against isolates from European and adjacent countries, including Enterobacteriaceae molecularly characterized for aminoglycoside-modifying enzymes and other resistance mechanisms.

Authors:  Mariana Castanheira; Lalitagauri M Deshpande; Leah N Woosley; Alisa W Serio; Kevin M Krause; Robert K Flamm
Journal:  J Antimicrob Chemother       Date:  2018-12-01       Impact factor: 5.790

2.  High prevalence of 16S rRNA methyltransferases among carbapenemase-producing Enterobacteriaceae in the UK and Ireland.

Authors:  Emma Taylor; Shiranee Sriskandan; Neil Woodford; Katie L Hopkins
Journal:  Int J Antimicrob Agents       Date:  2018-03-27       Impact factor: 5.283

Review 3.  Plazomicin: A New Aminoglycoside.

Authors:  Louis D Saravolatz; Gary E Stein
Journal:  Clin Infect Dis       Date:  2020-02-03       Impact factor: 9.079

Review 4.  Treatment of Infections Caused by Extended-Spectrum-Beta-Lactamase-, AmpC-, and Carbapenemase-Producing Enterobacteriaceae.

Authors:  Jesús Rodríguez-Baño; Belén Gutiérrez-Gutiérrez; Isabel Machuca; Alvaro Pascual
Journal:  Clin Microbiol Rev       Date:  2018-02-14       Impact factor: 26.132

5.  Carbapenem-resistant Klebsiella pneumoniae isolates from Egypt containing blaNDM-1 on IncR plasmids and its association with rmtF.

Authors:  Doaa Gamal; Marta Fernández-Martínez; Dalia Salem; Inas El-Defrawy; Laura Álvarez Montes; Alain A Ocampo-Sosa; Luis Martínez-Martínez
Journal:  Int J Infect Dis       Date:  2015-12-11       Impact factor: 3.623

Review 6.  Aminoglycoside Resistance: The Emergence of Acquired 16S Ribosomal RNA Methyltransferases.

Authors:  Yohei Doi; Jun-Ichi Wachino; Yoshichika Arakawa
Journal:  Infect Dis Clin North Am       Date:  2016-06       Impact factor: 5.982

7.  In Vitro Activity of Plazomicin Compared to Amikacin, Gentamicin, and Tobramycin against Multidrug-Resistant Aerobic Gram-Negative Bacilli.

Authors:  Wim A Fleischmann; Kerryl E Greenwood-Quaintance; Robin Patel
Journal:  Antimicrob Agents Chemother       Date:  2020-01-27       Impact factor: 5.191

8.  In vitro activity of Plazomicin against Enterobacteriaceae isolates carrying genes encoding aminoglycoside-modifying enzymes most common in US Census divisions.

Authors:  Mariana Castanheira; Andrew P Davis; Alisa W Serio; Kevin M Krause; Rodrigo E Mendes
Journal:  Diagn Microbiol Infect Dis       Date:  2018-12-05       Impact factor: 2.803

9.  Plazomicin Is Active Against Metallo-β-Lactamase-Producing Enterobacteriaceae.

Authors:  Alisa W Serio; Tiffany Keepers; Kevin M Krause
Journal:  Open Forum Infect Dis       Date:  2019-03-12       Impact factor: 3.835

10.  Nationwide epidemiology of carbapenem resistant Klebsiella pneumoniae isolates from Greek hospitals, with regards to plazomicin and aminoglycoside resistance.

Authors:  Irene Galani; Konstantina Nafplioti; Panagiota Adamou; Ilias Karaiskos; Helen Giamarellou; Maria Souli
Journal:  BMC Infect Dis       Date:  2019-02-15       Impact factor: 3.090
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  3 in total

1.  Synergistic antibacterial effects of colistin in combination with aminoglycoside, carbapenems, cephalosporins, fluoroquinolones, tetracyclines, fosfomycin, and piperacillin on multidrug resistant Klebsiella pneumoniae isolates.

Authors:  Julalak C Ontong; Nwabor F Ozioma; Supayang P Voravuthikunchai; Sarunyou Chusri
Journal:  PLoS One       Date:  2021-01-06       Impact factor: 3.240

2.  Multicenter Clinical Evaluation of ETEST Plazomicin (PLZ) for Susceptibility Testing of Enterobacterales.

Authors:  Laurine S Blanchard; Alex Van Belkum; Dominique Dechaume; Thomas P Armstrong; Christopher L Emery; Yun X Ying; Michael Kresken; Marion Pompilio; Diane Halimi; Gilles Zambardi
Journal:  J Clin Microbiol       Date:  2021-11-10       Impact factor: 5.948

Review 3.  Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections.

Authors:  Corneliu Ovidiu Vrancianu; Elena Georgiana Dobre; Irina Gheorghe; Ilda Barbu; Roxana Elena Cristian; Mariana Carmen Chifiriuc
Journal:  Microorganisms       Date:  2021-03-31
  3 in total

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