Literature DB >> 32152077

Levonadifloxacin, a Novel Benzoquinolizine Fluoroquinolone, Modulates Lipopolysaccharide-Induced Inflammatory Responses in Human Whole-Blood Assay and Murine Acute Lung Injury Model.

Anasuya Patel1, Ganesh V Sangle2, Jinal Trivedi1, Sushant A Shengule2, Deepak Thorve1, Mohan Patil2, Nitin J Deshmukh2, Bhushan Choudhari1, Avinash Karade1, Sangita Gupta1, Sachin Bhagwat1, Mahesh Patel3.   

Abstract

Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell count, myeloperoxidase, and cytokine levels. The immunomodulatory effect of levonadifloxacin, along with promising antibacterial activity, is expected to provide clinical benefits in the treatment of infections.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  acute lung injury; cytokine; fluoroquinolone; immunomodulatory; lipopolysaccharide; myeloperoxidase

Mesh：

Substances：

Year:  2020        PMID： 32152077      PMCID： PMC7179645          DOI： 10.1128/AAC.00084-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.

Authors:  Sachin S Bhagwat; Pamela McGhee; Klaudia Kosowska-Shick; Mahesh V Patel; Peter C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2008-11-24       Impact factor: 5.191

2.  Intrapulmonary Pharmacokinetics of Levonadifloxacin following Oral Administration of Alalevonadifloxacin to Healthy Adult Subjects.

Authors:  Keith A Rodvold; Mark H Gotfried; Rakesh Chugh; Mugdha Gupta; Ravindra Yeole; Anasuya Patel; Ashima Bhatia
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

3.  Activity of the new quinolone WCK 771 against pneumococci.

Authors:  P C Appelbaum; G A Pankuch; B Bozdogan; G Lin; M R Jacobs; M V Patel; S V Gupte; M A Jafri; N J De Souza; H F Khorakiwala
Journal:  Clin Microbiol Infect       Date:  2005-01       Impact factor: 8.067

Review 4.  Immunomodulatory activities of fluoroquinolones.

Authors:  A Dalhoff
Journal:  Infection       Date:  2005-12       Impact factor: 3.553

Review 5.  β-Lactam/macrolide dual therapy versus β-lactam monotherapy for the treatment of community-acquired pneumonia in adults: a systematic review and meta-analysis.

Authors:  Wei Nie; Bing Li; Qingyu Xiu
Journal:  J Antimicrob Chemother       Date:  2014-02-16       Impact factor: 5.790

Review 6.  Immunomodulating effects of antibiotics used in the prophylaxis of bacterial infections in advanced cirrhosis.

Authors:  Pedro Zapater; José Manuel González-Navajas; José Such; Rubén Francés
Journal:  World J Gastroenterol       Date:  2015-11-07       Impact factor: 5.742

Review 7.  Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view.

Authors:  Wibke Schulte; Jürgen Bernhagen; Richard Bucala
Journal:  Mediators Inflamm       Date:  2013-06-18       Impact factor: 4.711

Review 8.  Incidence, prevalence, and management of MRSA bacteremia across patient populations-a review of recent developments in MRSA management and treatment.

Authors:  Ali Hassoun; Peter K Linden; Bruce Friedman
Journal:  Crit Care       Date:  2017-08-14       Impact factor: 9.097

9.  Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome.

Authors:  Lang Li; Liang Dong; Dan Zhao; Fei Gao; Jie Yan
Journal:  Int J Mol Med       Date:  2019-05-23       Impact factor: 4.101

10.  New markers: urine xanthine oxidase and myeloperoxidase in the early detection of urinary tract infection.

Authors:  Pınar Ciragil; Ergul Belge Kurutas; Meral Miraloglu
Journal:  Dis Markers       Date:  2014-01-29       Impact factor: 3.434
View more
  1 in total

Review 1.  Potential new fluoroquinolone treatments for suspected bacterial keratitis.

Authors:  Rose Herbert; Mary Caddick; Tobi Somerville; Keri McLean; Shakeel Herwitker; Timothy Neal; Gabriela Czanner; Stephen Tuft; Stephen B Kaye
Journal:  BMJ Open Ophthalmol       Date:  2022-07
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.