Aloe vera-loaded nanofibrous scaffold based on Zein/Polycaprolactone/Collagen for wound healing.

Recently, the use of nanofibers (NFs) for tissue engineering has been more developed. For this purpose, we fabricated the NFs (Zein/Polycaprolactone/Collagen) (Zein/PCL/Collagen) incorporated by zinc oxide NPs (ZnO NPs) and Aloe-vera (NFs/ZnO/Alv) using the electrospinning method. Prepared NFs were studied for their morphological, mechanical, thermal stability, and hydrophilic properties. Among the developed NFs, those loaded by ZnO (1 wt%) and Alv (8 wt%) and with Zein/PCL (70:30) displayed the suitable thermal stability and mechanical properties. The water contact angle of NFs improved by decreasing the Zein/PCL blending ratio. Cell culture results showed that the NFs had good cytocompatibility. The cell adhesion potential of this mats were certified with studying by fibroblast cells for various time intervals (24 h and 72 h). The NFs/ZnO/Alv sample revealed inhibition activity against S. aureus (19.23 ± 1.35 mm) and E. coli (15.38 ± 1.12 mm) bacteria. Thus, these results offered that the prepared NFs can be promised as an active scaffold for wound healing uses.