Ingrid Amgarth-Duff1, Annmarie Hosie1,2, Gideon Caplan3,4, Meera Agar1,5,6. 1. IMPACCT (Improving Palliative, Aged and Chronic Care through Clinical Research and Translation), University of Technology Sydney, Sydney, New South Wales, Australia. 2. School of Nursing Sydney, University of Notre Dame Australia, Fremantle, Western Australia, Australia. 3. Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia. 4. Department of Geriatric Medicine, Prince of Wales Hospital, Sydney, New South Wales, Australia. 5. South West Sydney Clinical School, University of New South Wales, Liverpool, New South Wales, Australia. 6. Clinical Trials, Ingham Institute of Applied Medical Research, Liverpool, New South Wales, Australia.
Abstract
BACKGROUND: Delirium is a serious and distressing neurocognitive condition common in people with advanced illness. The understanding of delirium pathophysiology is limited and largely hypothetical. To accelerate empirical understanding of delirium pathophysiology, robust scientific methods for conducting and reporting delirium biomarker studies are urgently needed. The aim of this study was to develop international consensus on the core elements of high-quality delirium biomarker studies. METHODS: A three-round modified Delphi survey was conducted from February to August 2019. Participants were international researchers experienced in conducting delirium studies from a range of settings (hospital, university, research centres). Round one commenced with open-ended questions developed from results from a prior systematic review and the REMARK (REporting recommendations for tumour MARKer prognostic studies) checklist. Responses were qualitatively analysed, and closed statements were developed. Participants then ranked the importance of these statements using a 5-point Likert scale in rounds 2 and 3. A priori consensus was defined as ≥70% participant agreement. Descriptive statistics for each item were computed including the mean Likert scores, SD and median participant scores. RESULTS: Twenty-eight participants completed survey round one, 16 completed round two and 19 completed the final round. Consensus was achieved for a total of 60 items. CONCLUSION: The Delphi survey identified items that expert researchers agreed were important in the conduct of delirium biomarker studies. These reporting items provide a strong platform for improved methodological quality and opportunities to synthesise future delirium biomarker studies.
BACKGROUND: Delirium is a serious and distressing neurocognitive condition common in people with advanced illness. The understanding of delirium pathophysiology is limited and largely hypothetical. To accelerate empirical understanding of delirium pathophysiology, robust scientific methods for conducting and reporting delirium biomarker studies are urgently needed. The aim of this study was to develop international consensus on the core elements of high-quality delirium biomarker studies. METHODS: A three-round modified Delphi survey was conducted from February to August 2019. Participants were international researchers experienced in conducting delirium studies from a range of settings (hospital, university, research centres). Round one commenced with open-ended questions developed from results from a prior systematic review and the REMARK (REporting recommendations for tumour MARKer prognostic studies) checklist. Responses were qualitatively analysed, and closed statements were developed. Participants then ranked the importance of these statements using a 5-point Likert scale in rounds 2 and 3. A priori consensus was defined as ≥70% participant agreement. Descriptive statistics for each item were computed including the mean Likert scores, SD and median participant scores. RESULTS: Twenty-eight participants completed survey round one, 16 completed round two and 19 completed the final round. Consensus was achieved for a total of 60 items. CONCLUSION: The Delphi survey identified items that expert researchers agreed were important in the conduct of delirium biomarker studies. These reporting items provide a strong platform for improved methodological quality and opportunities to synthesise future delirium biomarker studies.
Authors: Sophia Wang; Ryan Greene; Yiqing Song; Carol Chan; Heidi Lindroth; Sikandar Khan; Gabriel Rios; Robert D Sanders; Babar Khan Journal: Int Psychogeriatr Date: 2022-01-17 Impact factor: 7.191
Authors: Amara Callistus Nwosu; Tamsin McGlinchey; Justin Sanders; Sarah Stanley; Jennifer Palfrey; Patrick Lubbers; Laura Chapman; Anne Finucane; Stephen Mason Journal: JMIR Aging Date: 2022-03-21