Anders Hjern1,2,3, Kristin Lindblom4, Antonia Reuter5, Sven-Arne Silfverdal6,7. 1. Sachs' Children and Youth hospital, Stockholm, Sweden. 2. Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden. 3. CHESS, Centre for Health Equity Studies, Stockholm University and Karolinska Institutet, Stockholm, Sweden. 4. Child Health Services, Dalecarlia region, Falun, Sweden. 5. Child and Youth Services, Primary Care, Västra Götaland region, Gothenburg, Sweden. 6. Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden. 7. Centre for Mother and Child Health Care, Region Västerbotten, Umeå, Sweden.
Abstract
AIM: The aim of this review was to evaluate the evidence for interventions for infantile colic. METHODS: This was a systematic review based on a literature search in December 2017 for articles published during 2007-2017 about preventive and treatment interventions for infantile colic in infants. The review included original randomised controlled trials (RCTs) and meta-analyses with at least 20 infants in each study group that were assessed according to GRADE criteria. RESULTS: The review found moderately strong evidence that administration of Lactobacillus reuteri DSM 17938 shortened the crying duration, with positive evidence from three out of four national contexts. There were four RCTs of acupuncture, all with no or minimal effect on crying duration. All studies reviewed with a follow-up until or beyond three months of age show a quite steep decline over time in crying duration in both treatment and control groups. CONCLUSION: Lactobacillus reuteri DSM 17938 is a promising treatment for infantile colic with moderately strong evidence in this review, but studies in more populations are needed. Acupuncture is not an effective treatment for infantile colic. Systematic support strategies to parents with infantile colic are important knowledge gaps.
AIM: The aim of this review was to evaluate the evidence for interventions for infantile colic. METHODS: This was a systematic review based on a literature search in December 2017 for articles published during 2007-2017 about preventive and treatment interventions for infantile colic in infants. The review included original randomised controlled trials (RCTs) and meta-analyses with at least 20 infants in each study group that were assessed according to GRADE criteria. RESULTS: The review found moderately strong evidence that administration of Lactobacillus reuteri DSM 17938 shortened the crying duration, with positive evidence from three out of four national contexts. There were four RCTs of acupuncture, all with no or minimal effect on crying duration. All studies reviewed with a follow-up until or beyond three months of age show a quite steep decline over time in crying duration in both treatment and control groups. CONCLUSION:Lactobacillus reuteri DSM 17938 is a promising treatment for infantile colic with moderately strong evidence in this review, but studies in more populations are needed. Acupuncture is not an effective treatment for infantile colic. Systematic support strategies to parents with infantile colic are important knowledge gaps.