Literature DB >> 32149283

l-Cysteine decorated nanoscale metal-organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy.

Wenna Guo1, Zengzhen Chen2, Longfei Tan3, Qiong Wu3, Xiangling Ren3, Changhui Fu3, Yongxing Du4, Jun Ren3, Xianwei Meng3.   

Abstract

We design multifunctional CDDP-VPA@ZrMOF-Cys-PEG nanoparticles (CVZP NPs) based on the properties of valproic acid (VPA) that can downregulate the expression of vascular endothelial growth factor (VEGF) to reduce the drug resistance of tumor cells. In vivo experiments confirm that chemotherapy combined with microwave thermal therapy (MWTT) can significantly improve the therapeutic effect of cisplatin-resistant lung cancer.

Entities:  

Year:  2020        PMID： 32149283     DOI： 10.1039/c9cc09712k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

Review 1.  The paradigm of drug resistance in cancer: an epigenetic perspective.

Authors:  Swagata Adhikari; Apoorva Bhattacharya; Santanu Adhikary; Vipin Singh; Shrikanth S Gadad; Siddhartha Roy; Chandrima Das
Journal:  Biosci Rep       Date:  2022-04-29       Impact factor: 3.976

Review 2.  Recent Advances and Implication of Bioengineered Nanomaterials in Cancer Theranostics.

Authors:  Ayushi Rai; Saba Noor; Syed Ishraque Ahmad; Mohamed F Alajmi; Afzal Hussain; Hashim Abbas; Gulam Mustafa Hasan
Journal:  Medicina (Kaunas)       Date:  2021-01-21       Impact factor: 2.430

3.  Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery.

Authors:  Saleheh Sanaei-Rad; Mohammad Ali Ghasemzadeh; Seyyed Mohammad Hossein Razavian
Journal:  Sci Rep       Date:  2021-09-21       Impact factor: 4.379
  3 in total

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