Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Vitamin C: an essential "stress hormone" during sepsis.

Literature DB >> 32148930

Vitamin C: an essential "stress hormone" during sepsis.

Abstract

The stress response is a preserved evolutionary response that functions to enhance the survival of the species. In mammals, the stress response is characterized by activation of the HPA axis and sympathoadrenal system (SAS) as well as the increased synthesis and secretion of vitamin C. Cortisol, catecholamines, and vitamin C act synergistically to increase hemodynamic reserve, maintain immune function and protect the host against excessive oxidant injury. Humans (and anthropoid apes) have lost the ability to synthesize vitamin C and therefore have an impaired stress response. The inability to produce vitamin C has serious implications in septic humans. Treatment with vitamin C appears to restore the stress response and improve the survival of stressed humans. 2020 Journal of Thoracic Disease. All rights reserved.

Entities: Chemical Disease Species

Keywords: HPA axis; Sepsis; stress response; vitamin C

Year: 2020 PMID： 32148930 PMCID： PMC7024758 DOI： 10.21037/jtd.2019.12.64

Source DB: PubMed Journal: J Thorac Dis ISSN： 2072-1439 Impact factor: 2.895

31 in total

1. A syndrome produced by diverse nocuous agents. 1936.

Authors: H Selye
Journal: J Neuropsychiatry Clin Neurosci Date: 1998 Impact factor: 2.198

2. Wide Interest in a Vitamin C Drug Cocktail for Sepsis Despite Lagging Evidence.

Authors: Rita Rubin
Journal: JAMA Date: 2019-07-23 Impact factor: 56.272

Review 3. Safety of vitamin C in sepsis: a neglected topic.

Authors: Niloofar Khoshnam-Rad; Hossein Khalili
Journal: Curr Opin Crit Care Date: 2019-08 Impact factor: 3.687

4. Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study.

Authors: Won-Young Kim; Eun-Jung Jo; Jung Seop Eom; Jeongha Mok; Mi-Hyun Kim; Ki Uk Kim; Hye-Kyung Park; Min Ki Lee; Kwangha Lee
Journal: J Crit Care Date: 2018-07-05 Impact factor: 3.425

5. Vitamin C deficiency and susceptibility to endotoxin shock in guinea pigs.

Authors: R N Fuller; E C Henson; E L Shannon; A D Collins; J G Brunson
Journal: Arch Pathol Date: 1971-10

6. A network-based analysis of systemic inflammation in humans.

Authors: Steve E Calvano; Wenzhong Xiao; Daniel R Richards; Ramon M Felciano; Henry V Baker; Raymond J Cho; Richard O Chen; Bernard H Brownstein; J Perren Cobb; S Kevin Tschoeke; Carol Miller-Graziano; Lyle L Moldawer; Michael N Mindrinos; Ronald W Davis; Ronald G Tompkins; Stephen F Lowry
Journal: Nature Date: 2005-08-31 Impact factor: 49.962

7. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.

Authors: Paul E Marik; Vikramjit Khangoora; Racquel Rivera; Michael H Hooper; John Catravas
Journal: Chest Date: 2016-12-06 Impact factor: 9.410

8. The adrenal-vitamin C axis: from fish to guinea pigs and primates.

Authors: Michael H Hooper; Anitra Carr; Paul E Marik
Journal: Crit Care Date: 2019-01-28 Impact factor: 9.097

9. The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.

Authors: David N Hager; Michael H Hooper; Gordon R Bernard; Laurence W Busse; E Wesley Ely; Alpha A Fowler; David F Gaieski; Alex Hall; Jeremiah S Hinson; James C Jackson; Gabor D Kelen; Mark Levine; Christopher J Lindsell; Richard E Malone; Anna McGlothlin; Richard E Rothman; Kert Viele; David W Wright; Jonathan E Sevransky; Greg S Martin
Journal: Trials Date: 2019-04-05 Impact factor: 2.279

10. Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?

Authors: Anitra C Carr; Geoffrey M Shaw; Alpha A Fowler; Ramesh Natarajan
Journal: Crit Care Date: 2015-11-27 Impact factor: 9.097

8 in total

1. β-Ionone Attenuates Dexamethasone-Induced Suppression of Collagen and Hyaluronic Acid Synthesis in Human Dermal Fibroblasts.

Authors: Dabin Choi; Wesuk Kang; Soyoon Park; Bomin Son; Taesun Park
Journal: Biomolecules Date: 2021-04-21

Review 2. Potential roles of micronutrient deficiency and immune system dysfunction in the coronavirus disease 2019 (COVID-19) pandemic.

Authors: Ali Gorji; Maryam Khaleghi Ghadiri
Journal: Nutrition Date: 2020-11-06 Impact factor: 4.008

7. Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study.

Authors: Cristian Arvinte; Maharaj Singh; Paul E Marik
Journal: Med Drug Discov Date: 2020-09-18

Review 8. Multi-Level Immune Support by Vitamins C and D during the SARS-CoV-2 Pandemic.

Authors: Anitra C Carr; Adrian F Gombart
Journal: Nutrients Date: 2022-02-06 Impact factor: 5.717