Patrick J Sparto1, Andrea L Rosso2, Ayushi A Divecha2, Andrea L Metti2, Caterina Rosano2. 1. Department of Physical Therapy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 2. Department of Epidemiology, Graduate School, of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Abstract
INTRODUCTION: Poor cognitive function and postural control co-occur in older adults. It is unclear whether they share neural substrates. METHODS: Postural sway error during a novel visual tracking (VT) condition and gray matter volume (GMV) were compared between participants with normal cognition (NC), mild cognitive impairment (MCI), or dementia (n = 179, mean age 82, 56% females, 56% white). Associations between VT error, cognitive function, and GMV were examined. RESULTS: Greater VT error was associated with having dementia compared to NC or MCI (odds ratio [95% CI] = 2.15 [1.38, 3.36] and 1.58 [1.05, 2.38]). Regions with lower GMV related to greater VT error and worse cognition were: bilateral hippocampi, parahippocampi, entorhinal, and parietal cortices (all P ≤0.05). GMV of bilateral hippocampi and left parahippocampus explained >20% of VT error between dementia and NC. DISCUSSION: Postural control during visuospatial tasks and dementia may share neural substrates, specifically memory-related regions.
INTRODUCTION: Poor cognitive function and postural control co-occur in older adults. It is unclear whether they share neural substrates. METHODS: Postural sway error during a novel visual tracking (VT) condition and gray matter volume (GMV) were compared between participants with normal cognition (NC), mild cognitive impairment (MCI), or dementia (n = 179, mean age 82, 56% females, 56% white). Associations between VT error, cognitive function, and GMV were examined. RESULTS: Greater VT error was associated with having dementia compared to NC or MCI (odds ratio [95% CI] = 2.15 [1.38, 3.36] and 1.58 [1.05, 2.38]). Regions with lower GMV related to greater VT error and worse cognition were: bilateral hippocampi, parahippocampi, entorhinal, and parietal cortices (all P ≤0.05). GMV of bilateral hippocampi and left parahippocampus explained >20% of VT error between dementia and NC. DISCUSSION: Postural control during visuospatial tasks and dementia may share neural substrates, specifically memory-related regions.
Authors: N Tzourio-Mazoyer; B Landeau; D Papathanassiou; F Crivello; O Etard; N Delcroix; B Mazoyer; M Joliot Journal: Neuroimage Date: 2002-01 Impact factor: 6.556
Authors: Caterina Rosano; Howard J Aizenstein; Stephanie Studenski; Anne B Newman Journal: J Gerontol A Biol Sci Med Sci Date: 2007-09 Impact factor: 6.053
Authors: Andrea L Rosso; Stephanie A Studenski; Wen G Chen; Howard J Aizenstein; Neil B Alexander; David A Bennett; Sandra E Black; Richard Camicioli; Michelle C Carlson; Luigi Ferrucci; Jack M Guralnik; Jeffrey M Hausdorff; Jeff Kaye; Lenore J Launer; Lewis A Lipsitz; Joe Verghese; Caterina Rosano Journal: J Gerontol A Biol Sci Med Sci Date: 2013-07-10 Impact factor: 6.053