Xitong Liu1, Wenhao Shi1, Juanzi Shi2. 1. Assisted Reproduction Center, Northwest Women's and Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, People's Republic of China. 2. Assisted Reproduction Center, Northwest Women's and Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, People's Republic of China. Electronic address: shijuanzi123@163.com.
Abstract
OBJECTIVE: To determine the optimal endometrial preparation protocols of frozen-thawed embryo transfer (FET) in young women with regular menstrual cycles. DESIGN: Retrospective cohort study. SETTING: Public fertility center. PATIENT(S): Infertile women with regular menstrual cycles undergoing FET. INTERVENTION(S): Natural cycle (NC) treatment for patients with proven ovulation in previous cycles or who refused medication (n = 308), or hormone treatment (HT) for patients who could not be frequently monitored (n = 1,538). MAIN OUTCOME MEASURE(S): Live-birth rates. RESULT(S): The live-birth rates were 61.73% in the NC group and 55.11% in the HT group. The effect size of the endometrial preparation on live-birth rates was evaluated in prespecified and exploratory subgroups in each subgroup, and multivariable logistic regression analysis was used to determine which variables could be independently associated with the live-birth rate. The HT patients had a lower chance of live birth in all subgroups: endometrial thickness on the day of progesterone administration, triple-line endometrial pattern, female age at embryo transfer, fertilization type, and protocol in the fresh cycle. Multivariable analysis showed NC to be associated with an increased likelihood of live birth compared with HT. CONCLUSION(S): Natural cycle treatment has a higher chance of live birth than HT for endometrial preparation in young women with regular menstrual cycles.
OBJECTIVE: To determine the optimal endometrial preparation protocols of frozen-thawed embryo transfer (FET) in young women with regular menstrual cycles. DESIGN: Retrospective cohort study. SETTING: Public fertility center. PATIENT(S): Infertilewomen with regular menstrual cycles undergoing FET. INTERVENTION(S): Natural cycle (NC) treatment for patients with proven ovulation in previous cycles or who refused medication (n = 308), or hormone treatment (HT) for patients who could not be frequently monitored (n = 1,538). MAIN OUTCOME MEASURE(S): Live-birth rates. RESULT(S): The live-birth rates were 61.73% in the NC group and 55.11% in the HT group. The effect size of the endometrial preparation on live-birth rates was evaluated in prespecified and exploratory subgroups in each subgroup, and multivariable logistic regression analysis was used to determine which variables could be independently associated with the live-birth rate. The HT patients had a lower chance of live birth in all subgroups: endometrial thickness on the day of progesterone administration, triple-line endometrial pattern, female age at embryo transfer, fertilization type, and protocol in the fresh cycle. Multivariable analysis showed NC to be associated with an increased likelihood of live birth compared with HT. CONCLUSION(S): Natural cycle treatment has a higher chance of live birth than HT for endometrial preparation in young women with regular menstrual cycles.
Authors: Xitong Liu; Wen Wen; Tao Wang; Ting Sun; Ting Wang; Na Zhang; Dan Pan; He Cai; Jinlin Xie; Xiaojuan Liu; Zan Shi; Rui Wang; Xiaofang Li; Na Lu; Rong Pan; Li Tian; Bin Meng; Haiyan Bai; Hanying Zhou; Pengfei Qu; Doudou Zhao; Ben W Mol; Wentao Li; Juanzi Shi Journal: BMJ Open Date: 2022-10-14 Impact factor: 3.006