| Literature DB >> 3214711 |
Y J van Megen1, A B Klaassen, J F Rodrigues de Miranda, W Kuijpers.
Abstract
Specific 3H-1-quinuclidinylbenzilate (3H-1-QNB) binding to rat cochlea homogenates occurs to a homogeneous class of binding sites with Kd = 0.13 +/- 0.01 nM and Bmax = 0.57 +/- 0.07 fmol per cochlea. Binding is stereoselectively inhibited by benzetimide enantiomers. Dexetimide was more effective than levetimide in displacing 3H-1-QNB from its binding sites (Ki = 4 x 10(-10) M and 6.5 x 10(-6) M, respectively). Pirenzepine inhibits 3H-1-QNB binding with low affinity (Ki = 2 x 10(-6) M), classifying the binding sites as muscarinic M2 receptors.Entities:
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Year: 1988 PMID： 3214711 DOI： 10.1016/0006-8993(88)90682-8
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252