Yu Meng1, Caoli Tang2, Jun Yu3, Shiyao Meng4, Wanying Zhang5. 1. School of Medicine, College of Arts & Science of Jianghan University, Wuhan 430000, China. Electronic address: mengyu9618@163.com. 2. School of Health Sciences, Wuhan University, Wuhan 430071, China. Electronic address: tcl_tang@163.com. 3. School of Health Sciences, Wuhan University, Wuhan 430071, China. Electronic address: junyu6699@whu.edu.cn. 4. School of Geodesy and Geomatics, Wuhan University, Wuhan 430079, China. Electronic address: mengshiyao@whu.edu.cn. 5. School of Medicine, College of Arts & Science of Jianghan University, Wuhan 430000, China. Electronic address: zwyyy7760@163.com.
Abstract
OBJECTIVE: To analyze the relationship between environmental lead exposure and various types of brain tumors. METHODS: Search databases PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure (CNKI) as of July 1, 2019. Stata 15.0 software was used for analysis. RESULTS: In the case control, lead exposure was associated with gliomas and meningiomas 0.82 (95 % CI: 0.69, 0.95) and 1.06 (95 % CI: 0.65, 1.46). In the cohort study, lead exposure was associated with brain cancer and meningiomas 1.07 (95 % CI: 0.95, 1.19) and 1.06 (95 % CI: 0.94, 1.17). The risk of childhood brain tumors associated with parental lead exposure was 1.17 (95 % CI: 0.99, 1.34). CONCLUSIONS: Lead may be a risk factor for meningiomas and brain cancers. However, the glioma results suggest that lead may be a protective factor, which needs to be further studied.
OBJECTIVE: To analyze the relationship between environmental lead exposure and various types of brain tumors. METHODS: Search databases PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure (CNKI) as of July 1, 2019. Stata 15.0 software was used for analysis. RESULTS: In the case control, lead exposure was associated with gliomas and meningiomas 0.82 (95 % CI: 0.69, 0.95) and 1.06 (95 % CI: 0.65, 1.46). In the cohort study, lead exposure was associated with brain cancer and meningiomas 1.07 (95 % CI: 0.95, 1.19) and 1.06 (95 % CI: 0.94, 1.17). The risk of childhood brain tumors associated with parental lead exposure was 1.17 (95 % CI: 0.99, 1.34). CONCLUSIONS: Lead may be a risk factor for meningiomas and brain cancers. However, the glioma results suggest that lead may be a protective factor, which needs to be further studied.