Vimal Bodiwala1, Timothy Marshall2, Kiron M Das1,3, Steven R Brant1,3, Darren N Seril1,3. 1. Department of Internal Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ. 2. School of Physical Therapy, Kean University, Union, NJ. 3. Crohn's and Colitis Center of New Jersey, Division of Gastroenterology and Hepatology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ.
Abstract
BACKGROUND: The prevalence and clinical features of inflammatory bowel disease (IBD) vary among different racial and ethnic groups. The aim of this study was to compare the clinical and phenotypic features of Crohn's disease (CD) and ulcerative colitis (UC) in South Asian patients living in the United States with those of a white cohort. METHODS: The demographic, clinical, and phenotypic characteristics of 73 South Asian patients (31 CD and 42 UC) who presented initially to our tertiary referral center from 2012 to 2016 and had subsequent follow-up were retrospectively compared with those of 408 consecutive white patients (245 CD and 163 UC). RESULTS: South Asian IBD patients were significantly more likely to have UC (58.0% vs 40.0%; P = 0.005) than white patients. South Asians with CD were less likely to have a family history of IBD (9.7% vs 26.9%; P = 0.037) and required fewer CD-related surgeries (22.5% vs 46.1; P = 0.012). South Asians were also less likely to be active or former smokers in both the CD (P = 0.004) and UC (P = 0.020) groups. South Asians with UC had a higher incidence of Clostridium difficile infection compared with white patients (19.0% vs 8.6%; P = 0.050). CONCLUSIONS: A cohort of South Asian patients with IBD were more likely to have UC and had differing family and tobacco risk factors, requirements for surgery, and Clostridium difficile infection rates as compared with white patients.
BACKGROUND: The prevalence and clinical features of inflammatory bowel disease (IBD) vary among different racial and ethnic groups. The aim of this study was to compare the clinical and phenotypic features of Crohn's disease (CD) and ulcerative colitis (UC) in South Asian patients living in the United States with those of a white cohort. METHODS: The demographic, clinical, and phenotypic characteristics of 73 South Asian patients (31 CD and 42 UC) who presented initially to our tertiary referral center from 2012 to 2016 and had subsequent follow-up were retrospectively compared with those of 408 consecutive white patients (245 CD and 163 UC). RESULTS: South Asian IBDpatients were significantly more likely to have UC (58.0% vs 40.0%; P = 0.005) than white patients. South Asians with CD were less likely to have a family history of IBD (9.7% vs 26.9%; P = 0.037) and required fewer CD-related surgeries (22.5% vs 46.1; P = 0.012). South Asians were also less likely to be active or former smokers in both the CD (P = 0.004) and UC (P = 0.020) groups. South Asians with UC had a higher incidence of Clostridium difficileinfection compared with white patients (19.0% vs 8.6%; P = 0.050). CONCLUSIONS: A cohort of South Asian patients with IBD were more likely to have UC and had differing family and tobacco risk factors, requirements for surgery, and Clostridium difficileinfection rates as compared with white patients.
Authors: J Dhaliwal; M W Carroll; J C deBruyn; A Ricciuto; E I Benchimol; S Lawrence; M Sherlock; W El-Matary; H Brill; P Church; E Wine; N Carman; A Muise; H Huynh; D R Mack; T D Walters; A M Griffiths; K Jacobson Journal: J Crohns Colitis Date: 2022-02-23 Impact factor: 10.020
Authors: Ana Gutiérrez; Pedro Zapater; Elena Ricart; María González-Vivó; Jordi Gordillo; David Olivares; Isabel Vera; Míriam Mañosa; Javier P Gisbert; Mariam Aguas; Eugenia Sánchez-Rodríguez; Maia Bosca-Watts; Viviana Laredo; Blau Camps; Ignacio Marín-Jiménez; Yamile Zabana; María Dolores Martín-Arranz; Roser Muñoz; Mercè Navarro; Eva Sierra; Lucía Madero; Milagros Vela; José Lázaro Pérez-Calle; Empar Sainz; Xavier Calvet; Lara Arias; Victor Morales; Fernando Bermejo; Luis Fernández-Salazar; Manuel Van Domselaar; Luisa De Castro; Cristina Rodríguez; Carmen Muñoz-Villafranca; Rufo Lorente; Montserrat Rivero; Eva Iglesias; Belén Herreros; David Busquets; Joan Riera; María Pilar Martínez-Montiel; Marta Roldón; Oscar Roncero; Esther Hinojosa; Mónica Sierra; Jesús Barrio; Ruth De Francisco; José Huguet; Olga Merino; Daniel Carpio; Daniel Ginard; Fernando Muñoz; Marta Piqueras; Pedro Almela; Federico Argüelles-Arias; Guillermo Alcaín; Luis Bujanda; Noemí Manceñido; Alfredo J Lucendo; Pilar Varela; Iago Rodríguez-Lago; Laura Ramos; Laura Sempere; Eva Sesé; Manuel Barreiro-de Acosta; Eugeni Domènech; Rubén Francés Journal: Front Med (Lausanne) Date: 2022-02-01