Hélène Bauer1, Paula Rios2, Gudrun Schleiermacher3, Dominique Valteau-Couanet4, Anne-Isabelle Bertozzi5, Estelle Thebaud6, Virginie Gandemer7, Isabelle Pellier8, Arnauld Verschuur9, Alexandra Spiegel10, Anne Notz-Carrere11, Christophe Bergeron12, Laurent Orsi1, Brigitte Lacour1,13,14, Jacqueline Clavel1,13,14. 1. CRESS, UMR1153, INSERM, Université de Paris, Villejuif, France. 2. CRESS, UMR1153, INSERM, Université de Paris, Villejuif, France. paula.rios@inserm.fr. 3. Institut Curie, Paris, France. 4. Children and Adolescent Cancerology Department, Gustave Roussy, Université Paris-Saclay, Villejuif, France. 5. CHU Toulouse, Hôpital Purpan, Toulouse, France. 6. CHU de Nantes, Hôtel Dieu, Nantes, France. 7. CHU de Rennes, Hôpital Sud, Rennes, France. 8. CHU D'Angers, Angers, France. 9. AP-HM, Hôpital La Timone, Marseille, France. 10. CHU de Strasbourg, Hôpital Hautepierre, Strasbourg, France. 11. CHU de Bordeaux, Hôpital Pellegrin, Bordeaux, France. 12. Centre Léon Bérard, IHOPe, Lyon, France. 13. National Registry of Childhood Cancers, APHP, CHU Paul Brousse, Villejuif, France. 14. CHU de Nancy, Nancy, France.
Abstract
PURPOSE: Wilms tumor (WT), or nephroblastoma, is an embryonic tumor that constitutes the most common renal tumor in children. Little is known about the etiology of WT. The aim of this study was to investigate whether maternal or perinatal characteristics were associated with the risk of WT. METHODS: The ESTELLE study is a national-based case-control study that included 117 cases of WT and 1,100 controls younger than 11 years old. The cases were children diagnosed in France in 2010-2011 and the controls were frequency matched with cases by age and gender. The mothers of case and control children responded to a telephone questionnaire addressing sociodemographic and perinatal characteristics, childhood environment, and lifestyle. Unconditional logistic regression models adjusted on potential cofounders were used to estimate the odds ratios (OR) and their confidence intervals (95% CI). RESULTS: High birth weight and the presence of congenital malformation were associated with WT (OR 1.9 [95% CI 1.0-3.7] and OR 2.5 [95% CI 1.1-5.8], respectively). No association with breastfeeding or folic acid supplementation was observed. CONCLUSIONS: Although potential recall bias cannot be excluded, our findings reinforce the hypothesis that high birth weight and the presence of congenital malformation may be associated with an increased risk of WT. Further investigations are needed to further elucidate the possible role of maternal characteristics in the etiology of WT.
PURPOSE:Wilms tumor (WT), or nephroblastoma, is an embryonic tumor that constitutes the most common renal tumor in children. Little is known about the etiology of WT. The aim of this study was to investigate whether maternal or perinatal characteristics were associated with the risk of WT. METHODS: The ESTELLE study is a national-based case-control study that included 117 cases of WT and 1,100 controls younger than 11 years old. The cases were children diagnosed in France in 2010-2011 and the controls were frequency matched with cases by age and gender. The mothers of case and control children responded to a telephone questionnaire addressing sociodemographic and perinatal characteristics, childhood environment, and lifestyle. Unconditional logistic regression models adjusted on potential cofounders were used to estimate the odds ratios (OR) and their confidence intervals (95% CI). RESULTS: High birth weight and the presence of congenital malformation were associated with WT (OR 1.9 [95% CI 1.0-3.7] and OR 2.5 [95% CI 1.1-5.8], respectively). No association with breastfeeding or folic acid supplementation was observed. CONCLUSIONS: Although potential recall bias cannot be excluded, our findings reinforce the hypothesis that high birth weight and the presence of congenital malformation may be associated with an increased risk of WT. Further investigations are needed to further elucidate the possible role of maternal characteristics in the etiology of WT.