L Klingelhoefer1, W Jost2, P Odin3, A Storch4,5, K Ray Chaudhuri6, H Reichmann7. 1. Klinik und Poliklinik für Neurologie, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland. Lisa.klingelhoefer@uniklinikum-dresden.de. 2. Parkinson-Klinik Ortenau, Kreuzbergstr. 12-16, 77709, Wolfach, Deutschland. 3. Division of Neurology, Skåne University Hospital, Lund University, Remissgatan 4, 22185, Lund, Schweden. 4. Klinik und Poliklinik für Neurologie, Universität Rostock, 18147, Rostock, Deutschland. 5. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Rostock/Greifswald, 18147, Rostock, Deutschland. 6. National Parkinson Foundation International Centre of Excellence, Department of Neurology, King's College Hospital, Denmark Hill, London, Großbritannien. 7. Klinik und Poliklinik für Neurologie, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland.
Abstract
BACKGROUND: Non-motor symptoms (NMS) in patients with dystonia have a relevant impact on health-related quality of life; however, a comprehensive easy to use NMS assessment tool for clinical bedside use is currently not available. OBJECTIVE: The validated German version of the dystonia non-motor symptoms questionnaire (DNMSQuest) for assessing NMS in craniocervical dystonia is presented. METHODS: The DNMSQuest in the German language was developed based on internationally recognized standards for intercultural adaptation of self-completed patient questionnaires. Translation of the original English questionnaire into the German language as well as back translation to English was carried out independently by four bilingual specialists in neurological movement disorders. In each case a consensus version accepted by each translator was created by another neurologist. The back translated English version was compared with the original English questionnaire for relevant linguistic and content discrepancies by a neurologist who was significantly involved in the development of the original questionnaire. The final German version was used in 130 patients with cervical dystonia and 48 healthy controls in an international, multicenter validation study. RESULTS: An interculturally adapted validated version of the DNMSQuest in the German and English languages was developed for rapid bedside assessment and evaluation of NMS in cervical dystonia. CONCLUSION: The DNMSQuest successfully bridges the current gap of a validated disease-specific, patient self-administered, short, comprehensive questionnaire for NMS assessment in routine clinical practice in craniocervical dystonia. It is envisaged that this tool will be useful for the clinical practice and trials.
BACKGROUND: Non-motor symptoms (NMS) in patients with dystonia have a relevant impact on health-related quality of life; however, a comprehensive easy to use NMS assessment tool for clinical bedside use is currently not available. OBJECTIVE: The validated German version of the dystonia non-motor symptoms questionnaire (DNMSQuest) for assessing NMS in craniocervical dystonia is presented. METHODS: The DNMSQuest in the German language was developed based on internationally recognized standards for intercultural adaptation of self-completed patient questionnaires. Translation of the original English questionnaire into the German language as well as back translation to English was carried out independently by four bilingual specialists in neurological movement disorders. In each case a consensus version accepted by each translator was created by another neurologist. The back translated English version was compared with the original English questionnaire for relevant linguistic and content discrepancies by a neurologist who was significantly involved in the development of the original questionnaire. The final German version was used in 130 patients with cervical dystonia and 48 healthy controls in an international, multicenter validation study. RESULTS: An interculturally adapted validated version of the DNMSQuest in the German and English languages was developed for rapid bedside assessment and evaluation of NMS in cervical dystonia. CONCLUSION: The DNMSQuest successfully bridges the current gap of a validated disease-specific, patient self-administered, short, comprehensive questionnaire for NMS assessment in routine clinical practice in craniocervical dystonia. It is envisaged that this tool will be useful for the clinical practice and trials.
Authors: Kallol Ray Chaudhuri; Pablo Martinez-Martin; Anthony H V Schapira; Fabrizio Stocchi; Kapil Sethi; Per Odin; Richard G Brown; William Koller; Paolo Barone; Graeme MacPhee; Linda Kelly; Martin Rabey; Doug MacMahon; Sue Thomas; William Ondo; David Rye; Alison Forbes; Susanne Tluk; Vandana Dhawan; Annette Bowron; Adrian J Williams; Charles W Olanow Journal: Mov Disord Date: 2006-07 Impact factor: 10.338
Authors: M Smit; A Kuiper; V Han; V C R Jiawan; G Douma; B van Harten; J M T H Oen; M E Pouwels; H J G Dieks; A L Bartels; M A Tijssen Journal: Parkinsonism Relat Disord Date: 2016-06-08 Impact factor: 4.891
Authors: Lynn Marie Trotti; Christine D Esper; Paul J Feustel; Donald L Bliwise; Stewart A Factor Journal: Parkinsonism Relat Disord Date: 2009-05-15 Impact factor: 4.891
Authors: Lisa Klingelhoefer; Kallol R Chaudhuri; Christoph Kamm; Pablo Martinez-Martin; Kailash Bhatia; Anna Sauerbier; Maximilian Kaiser; Carmen Rodriguez-Blazquez; Bettina Balint; Robert Untucht; Lynsey J Hall; Lauritz Mildenstein; Miriam Wienecke; Davide Martino; Olaf Gregor; Alexander Storch; Heinz Reichmann Journal: Ann Clin Transl Neurol Date: 2019-09-27 Impact factor: 4.511
Authors: Lisa Klingelhoefer; Maximilian Kaiser; Anna Sauerbier; Robert Untucht; Miriam Wienecke; Könül Mammadova; Björn Falkenburger; Olaf Gregor; K Ray Chaudhuri; Heinz Reichmann Journal: J Neural Transm (Vienna) Date: 2020-11-04 Impact factor: 3.575