Literature DB >> 32144337

Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury.

Shou-Yan Wu1,2, Wen-Jie Wang1,2, Jin-Hui Dou3, Li-Kun Gong4,5.   

Abstract

The first description of the medical use of licorice appeared in "Shennong Bencao Jing", one of the well-known Chinese herbal medicine classic books dated back to 220-280 AD. As one of the most commonly prescribed Chinese herbal medicine, licorice is known as "Guo Lao", meaning "a national treasure" in China. Modern pharmacological investigations have confirmed that licorice possesses a number of biological activities, such as antioxidation, anti-inflammatory, antiviral, immune regulation, and liver protection. 18β-glycyrrhetinic acid is one of the most extensively studied active integrants of licorice. Here, we provide an overview of the protective effects of 18β-glycyrrhetinic acid against various acute and chronic liver diseases observed in experimental models, and summarize its pharmacological effects and potential toxic/side effects at higher doses. We also make additional comments on the important areas that may warrant further research to support appropriate clinical applications of 18β-glycyrrhetinic acid and avoid potential risks.

Entities:  

Keywords:  18β-glycyrrhetic acid; glycyrrhetinic acid target; licorice preparation; liver injury

Mesh：

Substances：

Year:  2020        PMID： 32144337      PMCID： PMC7921636          DOI： 10.1038/s41401-020-0383-9

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   6.150


  80 in total

1.  18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.

Authors:  Shou-Yan Wu; Shi-Chao Cui; Le Wang; Yi-Ting Zhang; Xiao-Xia Yan; Heng-Lei Lu; Guo-Zhen Xing; Jin Ren; Li-Kun Gong
Journal:  Acta Pharmacol Sin       Date:  2018-07-30       Impact factor: 6.150

Review 2.  18β-Glycyrrhetinic acid: its core biological properties and dermatological applications.

Authors:  A Kowalska; U Kalinowska-Lis
Journal:  Int J Cosmet Sci       Date:  2019-06-28       Impact factor: 2.970

3.  18β-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediated immunosuppression in mice.

Authors:  Penghao Kuang; Wenxiu Zhao; Weixue Su; Zhengqi Zhang; Lei Zhang; Jianming Liu; Guangli Ren; Zhenyu Yin; Xiaomin Wang
Journal:  Int J Cancer       Date:  2012-10-20       Impact factor: 7.396

4.  Effect of 18β-glycyrrhetinic acid and hydroxypropyl γcyclodextrin complex on indomethacin-induced small intestinal injury in mice.

Authors:  Tsukasa Ishida; Ikuya Miki; Toshihito Tanahashi; Saori Yagi; Yasuyuki Kondo; Jun Inoue; Shoji Kawauchi; Sin Nishiumi; Masaru Yoshida; Hideko Maeda; Chisato Tode; Atsuko Takeuchi; Hirokazu Nakayama; Takeshi Azuma; Shigeto Mizuno
Journal:  Eur J Pharmacol       Date:  2013-06-19       Impact factor: 4.432

5.  Hydrolysis of glycyrrhizin to 18 beta-glycyrrhetyl monoglucuronide by lysosomal beta-D-glucuronidase of animal livers.

Authors:  T Akao; T Akao; M Hattori; M Kanaoka; K Yamamoto; T Namba; K Kobashi
Journal:  Biochem Pharmacol       Date:  1991 Mar 15-Apr 1       Impact factor: 5.858

6.  18β-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-α/ERK pathway.

Authors:  Hongke Cai; Xi Chen; Jianbo Zhang; Jijian Wang
Journal:  J Nat Med       Date:  2017-11-02       Impact factor: 2.343

7.  Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression.

Authors:  Hye Gwang Jeong; Ho Jin You; Sung Jun Park; Ae Ran Moon; Young Chul Chung; Shin Keon Kang; Hyo Kon Chun
Journal:  Pharmacol Res       Date:  2002-09       Impact factor: 7.658

8.  Social and anxiety-like behaviors contribute to nicotine self-administration in adolescent outbred rats.

Authors:  Tengfei Wang; Wenyan Han; Apurva S Chitre; Oksana Polesskaya; Leah C Solberg Woods; Abraham A Palmer; Hao Chen
Journal:  Sci Rep       Date:  2018-12-24       Impact factor: 4.379

Review 9.  Glycyrrhizic acid in the treatment of liver diseases: literature review.

Authors:  Jian-yuan Li; Hong-yan Cao; Ping Liu; Gen-hong Cheng; Ming-yu Sun
Journal:  Biomed Res Int       Date:  2014-05-13       Impact factor: 3.411

10.  Effects of 18β-Glycyrrhetinic Acid on Fungal Protease-Induced Airway Inflammatory Responses.

Authors:  Yun Hee Kim; Dong Eon Kim; Seung-Hyo Lee
Journal:  Mediators Inflamm       Date:  2018-05-15       Impact factor: 4.711
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  10 in total

1.  Endophytic fungi from Dongxiang wild rice (Oryza rufipogon Griff.) show diverse catalytic potential for converting glycyrrhizin.

Authors:  Yiwen Xiao; Zhibin Zhang; Weizhong Liang; Boliang Gao; Ya Wang; Jun Chang; Du Zhu
Journal:  3 Biotech       Date:  2022-02-26       Impact factor: 2.406

2.  Transcriptional profile changes after treatment of ischemia reperfusion injury-induced kidney fibrosis with 18β-glycyrrhetinic acid.

Authors:  Yamei Jiang; Chengzhe Cai; Pingbao Zhang; Yongsheng Luo; Jingjing Guo; Jiawei Li; Ruiming Rong; Yi Zhang; Tongyu Zhu
Journal:  Ren Fail       Date:  2022-12       Impact factor: 3.222

3.  18β-Glycyrrhetinic Acid Protects against Cholestatic Liver Injury in Bile Duct-Ligated Rats.

Authors:  Pin-Ho Pan; Ya-Yu Wang; Shih-Yi Lin; Su-Lan Liao; Yu-Fang Chen; Wei-Chi Huang; Chun-Jung Chen; Wen-Ying Chen
Journal:  Antioxidants (Basel)       Date:  2022-05-12

4.  Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation.

Authors:  Shouyan Wu; Henglei Lu; Wenjie Wang; Luyao Song; Meng Liu; Yuhan Cao; Xinming Qi; Jianhua Sun; Likun Gong
Journal:  Cell Death Dis       Date:  2021-05-13       Impact factor: 9.685

5.  Calycosin Induces Gastric Cancer Cell Apoptosis via the ROS-Mediated MAPK/STAT3/NF-κB Pathway.

Authors:  Yu Zhang; Jian-Qiang Zhang; Tong Zhang; Hui Xue; Wen-Bo Zuo; Yan-Nan Li; Yue Zhao; Geng Sun; Zhong-Ren Fu; Qing Zhang; Xue Zhao; Yue Teng; An-Qi Wang; Jia-Zhu Li; Ying Wang; Cheng-Hao Jin
Journal:  Onco Targets Ther       Date:  2021-04-12       Impact factor: 4.147

Review 6.  Drug-Induced Liver Injury: Highlights and Controversies in the Recent Literature.

Authors:  Joseph William Clinton; Sara Kiparizoska; Soorya Aggarwal; Stephanie Woo; William Davis; James H Lewis
Journal:  Drug Saf       Date:  2021-09-17       Impact factor: 5.606

Review 7.  In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism.

Authors:  Valery M Dembitsky
Journal:  Mar Drugs       Date:  2021-11-22       Impact factor: 5.118

8.  Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation.

Authors:  Zhangting Wang; Jiang Ma; Sheng Yao; Yisheng He; Kai-Kei Miu; Qingsu Xia; Peter P Fu; Yang Ye; Ge Lin
Journal:  Front Pharmacol       Date:  2022-03-16       Impact factor: 5.810

9.  18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs.

Authors:  Qian Zhang; Piao Luo; Liuhai Zheng; Jiayun Chen; Junzhe Zhang; Huan Tang; Dandan Liu; Xueling He; Qiaoli Shi; Liwei Gu; Jiahao Li; Qiuyan Guo; Chuanbin Yang; Yin Kwan Wong; Fei Xia; Jigang Wang
Journal:  J Pharm Anal       Date:  2022-06-08

10.  Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer.

Authors:  Guifeng Wang; Keiichi Hiramoto; Ning Ma; Nobuji Yoshikawa; Shiho Ohnishi; Mariko Murata; Shosuke Kawanishi
Journal:  Int J Mol Sci       Date:  2021-03-05       Impact factor: 5.923
  10 in total

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