| Literature DB >> 32142803 |
Elliot Lilley1, Melissa R Andrews2, Elizabeth J Bradbury3, Heather Elliott4, Penny Hawkins5, Ronaldo M Ichiyama6, Jo Keeley7, Adina T Michael-Titus8, Lawrence D F Moon9, Stefano Pluchino10, John Riddell11, Kathy Ryder12, Ping K Yip13.
Abstract
This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.Entities:
Keywords: Animal model; Animal welfare; Paralysis; Refinement; Regeneration; Spinal contusion; Spinal cord injury; Spinal transection; Three Rs; Tissue repair; Translational research
Mesh：
Year: 2020 PMID： 32142803 DOI： 10.1016/j.expneurol.2020.113273
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330