| Literature DB >> 32139519 |
Evelina Sjöstedt1,2, Wen Zhong2, Linn Fagerberg2, Max Karlsson2, Nicholas Mitsios1, Csaba Adori1, Per Oksvold2, Fredrik Edfors2, Agnieszka Limiszewska1, Feria Hikmet3, Jinrong Huang4,5,6,7, Yutao Du5,8, Lin Lin4,6, Zhanying Dong4,5,6, Ling Yang4,5,6, Xin Liu5,8, Hui Jiang9, Xun Xu5,8, Jian Wang5,8, Huanming Yang5,8, Lars Bolund4,5,6, Adil Mardinoglu2, Cheng Zhang2, Kalle von Feilitzen2, Cecilia Lindskog3, Fredrik Pontén3, Yonglun Luo4,5,6, Tomas Hökfelt1, Mathias Uhlén10,2, Jan Mulder10.
Abstract
The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain.Entities:
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Year: 2020 PMID： 32139519 DOI： 10.1126/science.aay5947
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728