Literature DB >> 32139431

Ratio of T1-Weighted to T2-Weighted Signal Intensity as a Measure of Tissue Integrity: Comparison with Magnetization Transfer Ratio in Patients with Multiple Sclerosis.

D Pareto1, A Garcia-Vidal2, M Alberich2, C Auger2, X Montalban3,4, M Tintoré3, J Sastre-Garriga3, À Rovira2.   

Abstract

The study aim was to compare the ratio of T1WI to T2WI signal intensity (T1/T2) with magnetization transfer ratio, a marker of myelin integrity, in patients with multiple sclerosis. A moderate correlation (r = 0.50, P = .034) was found between the magnetization transfer ratio and T1/T2 in normal-appearing gray matter, and a strong correlation for normal-appearing white matter (r = 0.63, P = .005) and lesions (r = 0.70, P = .001). Results suggest that besides myelin integrity, other factors may be playing a role in T1/T2 measures.
© 2020 by American Journal of Neuroradiology.

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Year:  2020        PMID： 32139431      PMCID： PMC7077893          DOI： 10.3174/ajnr.A6481

Source DB:  PubMed          Journal:  AJNR Am J Neuroradiol        ISSN： 0195-6108            Impact factor:   3.825


  7 in total

1.  Magnetization transfer in MRI: a review.

Authors:  R M Henkelman; G J Stanisz; S J Graham
Journal:  NMR Biomed       Date:  2001-04       Impact factor: 4.044

2.  Mapping human cortical areas in vivo based on myelin content as revealed by T1- and T2-weighted MRI.

Authors:  Matthew F Glasser; David C Van Essen
Journal:  J Neurosci       Date:  2011-08-10       Impact factor: 6.167

3.  T1-/T2-weighted ratio differs in demyelinated cortex in multiple sclerosis.

Authors:  Kunio Nakamura; Jacqueline T Chen; Daniel Ontaneda; Robert J Fox; Bruce D Trapp
Journal:  Ann Neurol       Date:  2017-09-21       Impact factor: 10.422

4.  Tissue damage within normal appearing white matter in early multiple sclerosis: assessment by the ratio of T1- and T2-weighted MR image intensity.

Authors:  A Beer; V Biberacher; P Schmidt; R Righart; D Buck; A Berthele; J Kirschke; C Zimmer; B Hemmer; M Mühlau
Journal:  J Neurol       Date:  2016-05-13       Impact factor: 4.849

5.  Cortical pathology in multiple sclerosis detected by the T1/T2-weighted ratio from routine magnetic resonance imaging.

Authors:  Ruthger Righart; Viola Biberacher; Laura E Jonkman; Roel Klaver; Paul Schmidt; Dorothea Buck; Achim Berthele; Jan S Kirschke; Claus Zimmer; Bernhard Hemmer; Jeroen J G Geurts; Mark Mühlau
Journal:  Ann Neurol       Date:  2017-09-16       Impact factor: 10.422

6.  Whole brain myelin mapping using T1- and T2-weighted MR imaging data.

Authors:  Marco Ganzetti; Nicole Wenderoth; Dante Mantini
Journal:  Front Hum Neurosci       Date:  2014-09-02       Impact factor: 3.169

7.  Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain.

Authors:  Klaus Schmierer; Francesco Scaravilli; Daniel R Altmann; Gareth J Barker; David H Miller
Journal:  Ann Neurol       Date:  2004-09       Impact factor: 10.422
  7 in total
  5 in total

1.  Investigating the relationship between multi-scale perfusion and white matter microstructural integrity in patients with relapsing-remitting MS.

Authors:  Nicholas J Sisco; Aimee Borazanci; Richard Dortch; Ashley M Stokes
Journal:  Mult Scler J Exp Transl Clin       Date:  2021-07-29

2.  Myelin damage and cortical atrophy in watershed regions in patients with moyamoya angiopathy.

Authors:  Elena Filimonova; Konstantin Ovsiannikov; Alexsey Sosnov; Artem Perfilyev; Rustam Gafurov; Dmitriy Galaktionov; Anatoliy Bervickiy; Vitaly Kiselev; Jamil Rzaev
Journal:  Front Neurosci       Date:  2022-08-23       Impact factor: 5.152

3.  Volume reduction without neuronal loss in the primate pulvinar complex following striate cortex lesions.

Authors:  Jonathan M Chan; Katrina H Worthy; Marcello G P Rosa; David H Reser; Nafiseh Atapour
Journal:  Brain Struct Funct       Date:  2021-07-29       Impact factor: 3.270

4.  Prediction and Visualization of Non-Enhancing Tumor in Glioblastoma via T1w/T2w-Ratio Map.

Authors:  Shota Yamamoto; Takahiro Sanada; Mio Sakai; Atsuko Arisawa; Naoki Kagawa; Eku Shimosegawa; Katsuyuki Nakanishi; Yonehiro Kanemura; Manabu Kinoshita; Haruhiko Kishima
Journal:  Brain Sci       Date:  2022-01-12

5.  Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation.

Authors:  Graham Cooper; Claudia Chien; Hanna Zimmermann; Judith Bellmann-Strobl; Klemens Ruprecht; Joseph Kuchling; Susanna Asseyer; Alexander U Brandt; Michael Scheel; Carsten Finke; Friedemann Paul
Journal:  Mult Scler       Date:  2021-04-15       Impact factor: 6.312
  5 in total

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