Adenohypophyseal tissue in an immature teratoma of the human ovary.

An immature ovarian teratoma containing adenohypophyseal tissue with a central arteriole and interpositioned in mature neural tissue is reported in an asymptomatic 31 -year-old woman. The tumor was a grade 2 immature teratoma according to the modified ThurlbeckScully histological grading system. Immunocytochemistry showed positive staining for growth hormone, prolactin, adrenocorticotropin, and alpha-subunit human chorionic gonodotropin and negative staining for thyroid-stimulating, follicle-stimulating, and luteinizing hormones in the adenohypophysis. The absence of staining for growth-hormonereleasing and corticotropin-releasing hormones, somatostatin, vasopressin, and neurophysin in adjacent tissue is consistent with the view that adenohypophyseal development is independent of the influence of these peptides.