| Literature DB >> 32135277 |
Raylane Adrielle Gonçalves Cambui1, Gilmar Ferreira do Espírito Santo2, Fernanda Pereira Fernandes3, Vinicius Nunes Cordeiro Leal3, Bianca Borsatto Galera4, Emerson Giuliano Palacio Fávaro5, Leonardo Amorim Rizzo6, Rosa Maria Elias6, Alessandra Pontillo3.
Abstract
Inflammation is a colorectal cancer (CRC) hallmark. Inflammasome-dependent cytokines IL-1ß and IL-18 can play a beneficial or detrimental role in tumorigenesis depending on cancer type. Variants in inflammasome genes were associated with tumor development and/or outcome, and have been proposed as potential biomarkers for population screening. In this study, 215 CRC patients followed-up for 10 years were examined for 9 polymorphisms in selected inflammasome genes. Multivariate association analysis and survival analysis were performed to evaluate the association between the polymorphisms and CRC prognosis. Variants associated with lower levels of IL-18 (rs1834481, rs5744256), or with increased activation of inflammasome receptors NLRP1 (rs12150220) and NLRP3 (rs35829419) resulted detrimental to CRC prognosis and may be used as prognostic markers.Entities:
Keywords: Colorectal cancer; IL18; Inflammasome; NLRP1; NLRP3; SNPs
Year: 2020 PMID： 32135277 DOI： 10.1016/j.clim.2020.108373
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969