| Literature DB >> 32134327 |
Yi Zhou1, Yanghua Fan1, Xi Zhou2, Anna Mou3, Yu He1, Fu Wang4, Yong Liu2.
Abstract
It is important to clarify the significance of long noncoding RNA MIR31 host gene (lncRNA MIR31HG) in predicting the prognosis for malignant tumors through meta-analysis. Electronic databases were systemically searched, from inception until 2 January 2019, to identify related articles. Meanwhile, the hazard ratios (odds ratios) and 95% CIs were computed for exploring the association between the expression of lncRNA MIR31HG and the survival (pathological variables). Eleven studies with 1041 cases were enrolled into the current meta-analysis. Low expression of lncRNA MIR31HG showed correlation with the dismal overall survival, disease-free survival, high tumor stage and lymph node metastasis among patients with digestive system cancers. Low expression of lncRNA MIR31HG may serve as a potential novel factor to indicate the dismal prognosis and metastasis in patients with digestive system cancers.Entities:
Keywords: MIR31HG; lncRNA; metastasis; neoplasm; prognosis
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Year: 2020 PMID： 32134327 DOI： 10.2217/bmm-2019-0145
Source DB: PubMed Journal: Biomark Med ISSN： 1752-0363 Impact factor: 2.851