Literature DB >> 321339

Mechanism of formation of non-immune rosettes between guinea-pig thymus-derived lymphocytes and rabbit erythrocytes.

H P Godfrey.   

Abstract

Several observations reported here suggest that spontaneous rosette formation between rabbit erythrocytes and guinea-pig T lymphocytes is mediated by natural anti-guinea-pig T-cell antibodies bound to the surface of the rabbit erythrocyte. First, normal rabbit sera frequently contain antibodies specifically cytotoxic for guinea-pig T lymphocytes. Second, the activity of rabbit erythrocytes in spontaneous rosette formation is reduced after incubation for 5 days at pH 6-1, but can be restored to levels seen with fresh erythrocytes by a brief incubation in normal rabbit serum containing natural anti-guinea-pig antibodies; normal serum absorbed with thymocytes does not restore activity to the erythrocytes. Third, the activity of rabbit erythrocytes in forming spontaneous rosettes can be specifically blocked by treatment with anti-allotype and heterologous anti-Ig sera.

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Year:  1977        PMID： 321339      PMCID： PMC1445194     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  11 in total

1.  Lymphocyte: erythrocyte (L.E.) rosettes as indicators of the heterogeneity of lymphocytes in a variety of mammalian species.

Authors:  C M Braganza; G Stathopoulos; A J Davies; E V Elliott; R S Kerbel; M Papamichail; E J Holborow
Journal:  Cell       Date:  1975-02       Impact factor: 41.582

2.  THE PHYSIOLOGICAL ROLE OF THE LYMPHOID SYSTEM, II. ERYTHROPHILIC gamma-GLOBULIN AND THE SURVIVAL OF THE ERYTHROCYTE.

Authors:  B V Fidalgo; V A Najjar; C F Zukoski; Y Katayama
Journal:  Proc Natl Acad Sci U S A       Date:  1967-03       Impact factor: 11.205

Review 3.  Receptors for complement and immunoglobulin on human and animal lymphoid cells.

Authors:  E M Shevach; E S Jaffe; I Green
Journal:  Transplant Rev       Date:  1973

4.  The physiological role of the lymphoid system. V. The binding of autologous (erythrophilic) gamma globulin to human red blood cells.

Authors:  B V Fidalgo; Y Katayama; V A Najjar
Journal:  Biochemistry       Date:  1967-11       Impact factor: 3.162

5.  Populations of guinea pig lymphocytes and Kurloff cells characterised by rosette-forming reactions.

Authors:  P A Revell; A B Wilson; R R Coombs
Journal:  Int Arch Allergy Appl Immunol       Date:  1974

6.  Rosette-formation between guinea pig lymphoid cells and rabbit erythrocytes--a possible T-cell marker.

Authors:  A B Wilson; R R Coombs
Journal:  Int Arch Allergy Appl Immunol       Date:  1973

Review 7.  Surface antigenic markers for distinguishing T and B lymphocytes in mice.

Authors:  M C Raff
Journal:  Transplant Rev       Date:  1971

Review 8.  Immunoglobulin allotypes of experimental animals.

Authors:  A S Kelus; P G Gell
Journal:  Prog Allergy       Date:  1967

9.  Rosette formation by guinea pig thymocytes and thymus derived lymphocytes with rabbit red blood cells.

Authors:  M J Stadecker; G Bishop; H H Wortis
Journal:  J Immunol       Date:  1973-12       Impact factor: 5.422

10.  Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.

Authors:  M Jondal; G Holm; H Wigzell
Journal:  J Exp Med       Date:  1972-08-01       Impact factor: 14.307
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