Dorra Ben Nessib1,2,3, Kaouther Maatallah4,5,6, Hanene Ferjani4,5,6, Dhia Kaffel4,5,6, Wafa Hamdi4,5,6. 1. Rheumatology Department, Kassab Orthopedics Institute, Mannouba, Tunisia. bennessibdorra@gmail.com. 2. Faculty of Medicine of Tunis, University Tunis el Manar, Tunis, Tunisia. bennessibdorra@gmail.com. 3. Research Unit UR17SP04, 2010, Ksar Said, Tunis, Tunisia. bennessibdorra@gmail.com. 4. Rheumatology Department, Kassab Orthopedics Institute, Mannouba, Tunisia. 5. Faculty of Medicine of Tunis, University Tunis el Manar, Tunis, Tunisia. 6. Research Unit UR17SP04, 2010, Ksar Said, Tunis, Tunisia.
Abstract
INTRODUCTION: Ramadan intermittent fasting is observed by Muslims from sunrise to sunset and alternated with moments of re-feeding. The aims of this study were to assess the impact of Ramadan fasting on rheumatoid arthritis (RA) and spondyloarthritis (SpA) activity and to assess its impact on chronic medications intake in patients with rheumatic diseases. METHODS: This prospective monocentric study included patients with RA or SpA who fasted during Ramadan of 2019. The disease activity and the managing of chronic medications were assessed and compared between two visits: the first one 6 months before starting Ramadan fasting and the second after fasting at least 7 days. RESULTS: Fifty-six patients were included: 36 with RA (average age 57.5 ± 10.9 years) and 20 with SpA (average age 47 ± 12.6 years). In the RA group, the Disease Activity Scores (DAS) 28 ESR, and DAS 28 CRP decreased after fasting respectively from 4.3 ± 1.3 to 3.5 ± 1.4 (p < 0.001) and from 3.4 ± 1.2 to 2.9 ± 1.3 (p = 0.001). In the SpA group, Ankylosing Spondylitis Disease Activity Scores (ASDAS) ESR and ASDAS CRP decreased respectively from 2.3 ± 0.5 to 1.9 ± 0.7 (p = 0.039) and from 1.9 ± 0.5 to 1.8 ± 0.8 (p = 0.388). Fasting did not affect significantly either compliance with chronic medications or tolerance. CONCLUSIONS: Fasting can be a possible way to induce rapid improvement of rheumatic diseases activity. In addition, patients with a specific fear of drug intake during this period can be reassured, which will enhance the adherence to treatment. Key Points • Fasting during Ramadan, the ninth month of the Islamic calendar, consists of intermittent fasting observed from sunrise to sunset. • In this set of patients, beneficial effects of intermittent fasting were demonstrated on RA activity, but were less evident in patients with SpA despite a general trend towards improvement. • Fasting did not affect significantly either compliance with chronic medications or tolerance.
INTRODUCTION: Ramadan intermittent fasting is observed by Muslims from sunrise to sunset and alternated with moments of re-feeding. The aims of this study were to assess the impact of Ramadan fasting on rheumatoid arthritis (RA) and spondyloarthritis (SpA) activity and to assess its impact on chronic medications intake in patients with rheumatic diseases. METHODS: This prospective monocentric study included patients with RA or SpA who fasted during Ramadan of 2019. The disease activity and the managing of chronic medications were assessed and compared between two visits: the first one 6 months before starting Ramadan fasting and the second after fasting at least 7 days. RESULTS: Fifty-six patients were included: 36 with RA (average age 57.5 ± 10.9 years) and 20 with SpA (average age 47 ± 12.6 years). In the RA group, the Disease Activity Scores (DAS) 28 ESR, and DAS 28 CRP decreased after fasting respectively from 4.3 ± 1.3 to 3.5 ± 1.4 (p < 0.001) and from 3.4 ± 1.2 to 2.9 ± 1.3 (p = 0.001). In the SpA group, Ankylosing Spondylitis Disease Activity Scores (ASDAS) ESR and ASDAS CRP decreased respectively from 2.3 ± 0.5 to 1.9 ± 0.7 (p = 0.039) and from 1.9 ± 0.5 to 1.8 ± 0.8 (p = 0.388). Fasting did not affect significantly either compliance with chronic medications or tolerance. CONCLUSIONS: Fasting can be a possible way to induce rapid improvement of rheumatic diseases activity. In addition, patients with a specific fear of drug intake during this period can be reassured, which will enhance the adherence to treatment. Key Points • Fasting during Ramadan, the ninth month of the Islamic calendar, consists of intermittent fasting observed from sunrise to sunset. • In this set of patients, beneficial effects of intermittent fasting were demonstrated on RA activity, but were less evident in patients with SpA despite a general trend towards improvement. • Fasting did not affect significantly either compliance with chronic medications or tolerance.
Authors: Jesse P Caron; Margaret Ann Kreher; Angela M Mickle; Stanley Wu; Rene Przkora; Irene M Estores; Kimberly T Sibille Journal: Nutrients Date: 2022-06-18 Impact factor: 6.706
Authors: Mohamed Negm; Ahmed Bahaa; Ahmed Farrag; Rania M Lithy; Hedy A Badary; Mahmoud Essam; Shimaa Kamel; Mohamed Sakr; Waleed Abd El Aaty; Mostafa Shamkh; Ahmed Basiony; Ibrahim Dawoud; Hany Shehab Journal: BMC Gastroenterol Date: 2022-04-24 Impact factor: 2.847
Authors: Stefan Lucian Popa; Dinu Iuliu Dumitrascu; Vlad Dumitru Brata; Traian Adrian Duse; Maria Delia Florea; Abdulrahman Ismaiel; Laura Mirela Muntean; Simona Grad Journal: Nutrients Date: 2022-03-17 Impact factor: 5.717