Trang Nguyen1, Tobias Bartscht2, Steven E Schild3, Dirk Rades4. 1. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany. 2. Department of Medical Oncology and Hematology, University of Lübeck, Lübeck, Germany. 3. Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A. 4. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
Abstract
BACKGROUND/AIM: Treatment of elderly patients with cancer has increasing importance. Since many of these patients may not tolerate standard treatments, they might benefit from personalized approaches. This study was performed to identify characteristics that allow estimation of survival in elderly patients with prostate cancer with cerebral metastases. PATIENTS AND METHODS: Data of 21 elderly patients (≥65 years) receiving whole-brain radiotherapy (WBRT) for cerebral metastases from prostate cancer were retrospectively evaluated. Six characteristics were investigated: WBRT program, age, Karnofsky performance score (KPS), number of brain metastases, extra-cerebral metastases, and interval between diagnosis of prostate cancer and WBRT. RESULTS: On univariate analyses, KPS ≥80% resulted in better survival than KPS ≤70% (log-rank p=0.018). Three-month survival was 60% vs. 36%, and 6-month survival 50% vs. 0%, respectively. In the Cox model, KPS maintained significance (hazard ratio=3.18, p=0.031). CONCLUSION: KPS is a significant prognostic factor of survival in elderly patients with prostate cancer receiving WBRT for cerebral metastases. Copyright
BACKGROUND/AIM: Treatment of elderly patients with cancer has increasing importance. Since many of these patients may not tolerate standard treatments, they might benefit from personalized approaches. This study was performed to identify characteristics that allow estimation of survival in elderly patients with prostate cancer with cerebral metastases. PATIENTS AND METHODS: Data of 21 elderly patients (≥65 years) receiving whole-brain radiotherapy (WBRT) for cerebral metastases from prostate cancer were retrospectively evaluated. Six characteristics were investigated: WBRT program, age, Karnofsky performance score (KPS), number of brain metastases, extra-cerebral metastases, and interval between diagnosis of prostate cancer and WBRT. RESULTS: On univariate analyses, KPS ≥80% resulted in better survival than KPS ≤70% (log-rank p=0.018). Three-month survival was 60% vs. 36%, and 6-month survival 50% vs. 0%, respectively. In the Cox model, KPS maintained significance (hazard ratio=3.18, p=0.031). CONCLUSION: KPS is a significant prognostic factor of survival in elderly patients with prostate cancer receiving WBRT for cerebral metastases. Copyright
Authors: Kobisha Rajeswaran; Kaitlin Muzio; Juan Briones; Mary Jane Lim-Fat; Chia-Lin Tseng; Martin Smoragiewicz; Jay Detsky; Urban Emmenegger Journal: J Clin Med Date: 2022-07-18 Impact factor: 4.964