BACKGROUND: Metastatic head and neck cancers (HNCs) predominantly affect the lungs and have a two-year overall survival (OS) of 15% to 50%, if amenable for pulmonary metastasectomy. METHODS: Retrospective review of the two-year local control (LC), local-regional control (LRC) within the same lobe, OS, and toxicity rates in consecutive patients with metastatic pulmonary HNC who underwent stereotactic ablative radiotherapy (SABR) January 2007 to May 2018. RESULTS: Evaluated 82 patients with 107 lung lesions, most commonly squamous cell carcinoma (SCC; 64%). Median follow-up was 20 months (range: 9.0-97.6). Systemic therapy administered in 34%. LC, LRC, and OS rates were 94%, 90%, and 62%. Patients with oligometastatic disease had a higher OS than polymetastatic disease, 72% vs 44% (HR = 0.30, 95% CI: 0.14-0.64; P = .008). OS in oligometastatic non-SCC and SCC were 100% and 66% (P = .03). There were no grade ≥3 toxicities. CONCLUSIONS: Metastatic pulmonary HNCs after SABR have a two-year OS rate comparable to pulmonary metastasectomy.
BACKGROUND: Metastatic head and neck cancers (HNCs) predominantly affect the lungs and have a two-year overall survival (OS) of 15% to 50%, if amenable for pulmonary metastasectomy. METHODS: Retrospective review of the two-year local control (LC), local-regional control (LRC) within the same lobe, OS, and toxicity rates in consecutive patients with metastatic pulmonary HNC who underwent stereotactic ablative radiotherapy (SABR) January 2007 to May 2018. RESULTS: Evaluated 82 patients with 107 lung lesions, most commonly squamous cell carcinoma (SCC; 64%). Median follow-up was 20 months (range: 9.0-97.6). Systemic therapy administered in 34%. LC, LRC, and OS rates were 94%, 90%, and 62%. Patients with oligometastatic disease had a higher OS than polymetastatic disease, 72% vs 44% (HR = 0.30, 95% CI: 0.14-0.64; P = .008). OS in oligometastatic non-SCC and SCC were 100% and 66% (P = .03). There were no grade ≥3 toxicities. CONCLUSIONS: Metastatic pulmonary HNCs after SABR have a two-year OS rate comparable to pulmonary metastasectomy.
Authors: Steven Borson; Yongli Shuai; Barton F Branstetter; Marci Lee Nilsen; Marion A Hughes; Moon Fenton; Mark Kubik; Shaum Sridharan; David A Clump; Heath D Skinner; Jonas T Johnson; Simion I Chiosea; James Ohr; Umamaheswar Duvvuri; Seungwon Kim; Katie S Traylor; Robert Ferris; Dan P Zandberg Journal: Laryngoscope Investig Otolaryngol Date: 2022-05-06
Authors: Thomas Weissmann; Daniel Höfler; Markus Hecht; Sabine Semrau; Marlen Haderlein; Irina Filimonova; Benjamin Frey; Christoph Bert; Sebastian Lettmaier; Konstantinos Mantsopoulos; Heinrich Iro; Rainer Fietkau; Florian Putz Journal: Radiat Oncol Date: 2021-03-31 Impact factor: 3.481
Authors: Ciro Franzese; M Badalamenti; A Teriaca; A De Virgilio; G Mercante; R Cavina; D Ferrari; A Santoro; G Spriano; M Scorsetti Journal: J Cancer Res Clin Oncol Date: 2021-01-20 Impact factor: 4.553