Shengrong Wan1,2, Man Guo1,2, Ting Zhang1, Qing Chen1,2, Maoyan Wu1,2, Fangyuan Teng1, Yang Long1, Zongzhe Jiang1, Yong Xu1,2. 1. Luzhou Key Laboratory of Cardiovascular and Metabolic Diseases, Affiliated Hospital of Southwest Medical University, Luzhou, China. 2. Department of Diabetes and Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Abstract
OBJECTIVE: This study aimed to investigate whether antibiotic exposure during pregnancy and infancy was associated with childhood overweight or obesity. METHODS: PubMed, Embase, and Cochrane Library databases were searched from the inception date to April 18, 2019, to identify observational studies that investigated the association between antibiotic exposure during pregnancy and infancy and childhood overweight or obesity. After study selection and data extraction, the meta-analysis was conducted using Stata software version 12.0 (StataCorp LP, College Station, Texas). The evaluation of the methodological quality was carried out by AMSTAR 2 (Bruyère Research Institute, Ottawa, Ontario, Canada). RESULTS: A total of 23 observational studies involving 1,253,035 participants were included. The meta-analysis showed that prenatal exposure to antibiotics was not significantly associated with childhood overweight or obesity, whereas an increased risk of overweight or obesity was seen in subgroup analysis of the second trimester (risk ratio = 1.13; 95% CI: 1.06-1.22; P = 0.001). In contrast, antibiotic exposure during infancy could increase the risk of childhood overweight or obesity (risk ratio = 1.14; 95% CI: 1.06-1.23; P = 0.001). CONCLUSIONS: This meta-analysis found that antibiotic exposure during the second trimester and infancy could increase the risk of childhood overweight or obesity.
OBJECTIVE: This study aimed to investigate whether antibiotic exposure during pregnancy and infancy was associated with childhood overweight or obesity. METHODS: PubMed, Embase, and Cochrane Library databases were searched from the inception date to April 18, 2019, to identify observational studies that investigated the association between antibiotic exposure during pregnancy and infancy and childhood overweight or obesity. After study selection and data extraction, the meta-analysis was conducted using Stata software version 12.0 (StataCorp LP, College Station, Texas). The evaluation of the methodological quality was carried out by AMSTAR 2 (Bruyère Research Institute, Ottawa, Ontario, Canada). RESULTS: A total of 23 observational studies involving 1,253,035 participants were included. The meta-analysis showed that prenatal exposure to antibiotics was not significantly associated with childhood overweight or obesity, whereas an increased risk of overweight or obesity was seen in subgroup analysis of the second trimester (risk ratio = 1.13; 95% CI: 1.06-1.22; P = 0.001). In contrast, antibiotic exposure during infancy could increase the risk of childhood overweight or obesity (risk ratio = 1.14; 95% CI: 1.06-1.23; P = 0.001). CONCLUSIONS: This meta-analysis found that antibiotic exposure during the second trimester and infancy could increase the risk of childhood overweight or obesity.
Authors: Rebecca M Lebeaux; Juliette C Madan; Quang P Nguyen; Modupe O Coker; Erika F Dade; Yuka Moroishi; Thomas J Palys; Benjamin D Ross; Melinda M Pettigrew; Hilary G Morrison; Margaret R Karagas; Anne G Hoen Journal: Pediatr Res Date: 2022-05-14 Impact factor: 3.953
Authors: Debmalya Nandy; Sarah J C Craig; Jingwei Cai; Yuan Tian; Ian M Paul; Jennifer S Savage; Michele E Marini; Emily E Hohman; Matthew L Reimherr; Andrew D Patterson; Kateryna D Makova; Francesca Chiaromonte Journal: Pediatr Obes Date: 2021-07-30 Impact factor: 3.910