Literature DB >> 32127486

Partial ALDH inhibition to facilitate controlled drinking rather than abstinence has already been tried and it works.

Colin Brewer1.   

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Year:  2020        PMID： 32127486      PMCID： PMC7148581          DOI： 10.1073/pnas.2000318117

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  6 in total

1.  Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele.

Authors:  Y C Chen; R B Lu; G S Peng; M F Wang; H K Wang; H C Ko; Y C Chang; J J Lu; T K Li; S J Yin
Journal:  Alcohol Clin Exp Res       Date:  1999-12       Impact factor: 3.455

2.  Reduction of ethanol consumption in alcohol-preferring rats by dual expression gene transfer.

Authors:  Mario Rivera-Meza; María Elena Quintanilla; Lutske Tampier
Journal:  Alcohol Alcohol       Date:  2012-01-02       Impact factor: 2.826

3.  A new double medication method for the treatment of alcoholism using the drug cyanamide.

Authors:  H Mukasa; K Arikawa
Journal:  Kurume Med J       Date:  1968

4.  Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking.

Authors:  Adrien Guillot; Tianyi Ren; Tony Jourdan; Robert J Pawlosky; Elaine Han; Seung-Jin Kim; Li Zhang; George F Koob; Bin Gao
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-02       Impact factor: 11.205

5.  Contribution of genetic polymorphisms in ethanol-metabolizing enzymes to problem drinking behavior in middle-aged Japanese men.

Authors:  Fang Sun; Ikiko Tsuritani; Yuichi Yamada
Journal:  Behav Genet       Date:  2002-07       Impact factor: 2.805

6.  To keep the alcoholic in out-patient treatment. A differentiated approach through treatment contracts.

Authors:  A Ojehagen; M Berglund
Journal:  Acta Psychiatr Scand       Date:  1986-01       Impact factor: 6.392
  6 in total
  1 in total

1.  Reply to Brewer: Liver-targeted ALDH2 inhibition may reduce alcohol-seeking behaviors with limited side effects.

Authors:  Adrien Guillot; George F Koob; Bin Gao
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-03       Impact factor: 11.205
  1 in total

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