Eva McCabe1,2, Ammar Ibrahim3,4, Rajneet Singh3,4, Michael Kelly5, Catherine Armstrong3,4, Fiona Heaney3,4, Diane Bergin6, John P McCabe3,5, John J Carey3,4. 1. School of Medicine, National University of Ireland, Galway, Ireland. eva.mccabe@nuigalway.ie. 2. Department of Rheumatology, Galway University Hospital, Galway, Ireland. eva.mccabe@nuigalway.ie. 3. School of Medicine, National University of Ireland, Galway, Ireland. 4. Department of Rheumatology, Galway University Hospital, Galway, Ireland. 5. Department of Trauma and Orthopaedic Surgery, Galway University Hospital, Galway, Ireland. 6. Department of Radiology, Galway University Hospital, Galway, Ireland.
Abstract
INTRODUCTION: Vertebral fractures (VF) are the most common osteoporotic fracture. They are associated with significant morbidity and mortality and are an important predictor of future fractures. The epidemiology of VF in Ireland is limited and a greater understanding of their scale and impact is needed. Therefore, we conducted a systematic review of publications on osteoporotic VF in Ireland. METHODS: Systematic searches were conducted using PubMed, Medline, Embase, Scopus and Cochrane electronic databases to identify eligible publications from Ireland addressing osteoporotic VF. RESULTS: Twenty studies met the inclusion criteria out of 1558 citations. All studies were published since 2000. Data was obtained on 182,771 patients with fractures. Nine studies included more than 100 subjects and three included more than 1000. Females accounted for 70% with an overall mean age of 65.2 years (30-94). There was significant heterogeneity in study design, methods and outcome measures including the following: use of administrative claims data on public hospital admissions, surgical and medical interventions, the impact of a fracture liaison service and the osteoporosis economic burden. The prevalence of VF was difficult to ascertain due to definitions used and differences in the study populations. Only two studies systematically reviewed spine imaging using blinded assessors and validated diagnostic criteria to assess the prevalence of fractures in patient cohorts. CONCLUSIONS: Several studies show that VF are common when addressed systematically and the prevalence may be rising. However, there is a deficit of large studies systematically addressing the epidemiology and their importance in Ireland.
INTRODUCTION:Vertebral fractures (VF) are the most common osteoporotic fracture. They are associated with significant morbidity and mortality and are an important predictor of future fractures. The epidemiology of VF in Ireland is limited and a greater understanding of their scale and impact is needed. Therefore, we conducted a systematic review of publications on osteoporotic VF in Ireland. METHODS: Systematic searches were conducted using PubMed, Medline, Embase, Scopus and Cochrane electronic databases to identify eligible publications from Ireland addressing osteoporotic VF. RESULTS: Twenty studies met the inclusion criteria out of 1558 citations. All studies were published since 2000. Data was obtained on 182,771 patients with fractures. Nine studies included more than 100 subjects and three included more than 1000. Females accounted for 70% with an overall mean age of 65.2 years (30-94). There was significant heterogeneity in study design, methods and outcome measures including the following: use of administrative claims data on public hospital admissions, surgical and medical interventions, the impact of a fracture liaison service and the osteoporosis economic burden. The prevalence of VF was difficult to ascertain due to definitions used and differences in the study populations. Only two studies systematically reviewed spine imaging using blinded assessors and validated diagnostic criteria to assess the prevalence of fractures in patient cohorts. CONCLUSIONS: Several studies show that VF are common when addressed systematically and the prevalence may be rising. However, there is a deficit of large studies systematically addressing the epidemiology and their importance in Ireland.
Authors: John J Carey; Lan Yang; E Erjiang; Tingyan Wang; Kelly Gorham; Rebecca Egan; Attracta Brennan; Mary Dempsey; Catherine Armstrong; Fiona Heaney; Eva McCabe; Ming Yu Journal: Calcif Tissue Int Date: 2021-06-03 Impact factor: 4.333