Healthcare Access as a Risk-Marker for Obstetric Vesicovaginal Fistula in Malawi.

OBJECTIVES: To determine the association between access to health care among pregnant women in Malawi and occurrence of obstetric vesicovaginal fistula (VVF).
METHODS: This was a case-control study using data obtained from patients' records documented by the 'Fistula Care Center-Bwaila Hospital' in Malawi. Socio-demographic characteristics of women with VVF (study arm, n=1046) and perineal tear (control arm, n=37) were examined. A composite variable called "Malawi Healthcare Access Index" (MHAI) was created through summation of scores related to three factors of access to care: (1) walking distance to closest health center; (2) presence of trained provider at delivery; and (3) receipt of antenatal care. Binomial logistic regression models were built to determine the association between the MHAI and presence of VVF.
RESULTS: Obstetric VVF was more common in women from rural areas, mothers delivering at extremes of age, those with less education, and patients with long labor (>12 hours). In adjusted models, women with "insufficient" health access based on the MHAI were at greater risk (OR = 2.64, 95%CI = 1.07 - 6.03) of obstetric VVF than women with "sufficient" score on the MHAI. CONCLUSION AND GLOBAL HEALTH IMPLICATIONS: Inadequate access to essential obstetric care increases the risk of VVF.

1. Introduction

1.1. Background of the Study

Obstetric vesicovaginal fistula (VVF) is a devastating outcome of childbirth which occurs almost exclusively in women living in extreme poverty in developing countries.1

Eradicated in industrialized nations, obstetric VVF results from failure to provide women with adequate access to obstetric health services and, most essentially, safe cesarean delivery. Obstructed labor, or when there is failure of delivery to occur in a normal time period, is thought to occur in about four percent of births worldwide, impacting over six million women annually with the vast majority of cases occurring in developing countries.2 For those women surviving the labor, one of the worst long-term consequences is the development of a VVF.

Obstetric VVF is a condition in which a connection occurs between the vagina and the bladder resulting in uncontrolled leakage of urine.3 It is most frequently caused by obstructed labor when prolonged fetal head compression leads to ischemia of tissues of the vagina and the urinary tract which eventually sloughs off creating a “hole” in the vagina and bladder.4,5 This abnormal connection causes continuous leakage of urine from the vagina, which frequently sets off a downward social and economic spiral. These extremely vulnerable women, often at the extremes of reproductive age, usually suffer the devastating outcome of stillbirth during the delivery in addition to fistula formation.4 The combination of continuous odor from uncontrolled urine and loss of a child leads to stigma, powerlessness, isolation, and often ultimately results in total abandonment of a women by her spouse, family and community.6,7 It is estimated that well over 2 million women suffer from untreated obstetric fistulas in Asia and sub-Saharan Africa, with 50,000-100,000 new cases occurring annually.8

In Malawi, the prevalence of fistula is estimated to be 1.6 per 1000 women.9 Though 85-95% of obstetric fistulas are correctable through surgical repair, access to centers of treatment is limited, requires extended hospital stays and staff with advanced training.10-12 While efforts to repair those affected are being made, prevention of new cases is required to eradicate fistula. As the development of functional health systems capable of providing quality maternity care including widespread access to cesarean delivery in developing countries is decades away at best, interim solutions must be sought through targeting of modifiable risk factors.

Moreover, commonly discussed risk factors for development of obstetric fistula include delivery outside of a health center, absence of skilled birthing attendant, prolonged duration of labor, early age at time of marriage, and lack of prenatal care.13-15 However, risk factors vary significantly by country and patient population.

This study sought to identify risk factors for development of obstetric fistula for women seeking care for fistula in Lilongwe, Malawi, in hopes of assisting in the development of effective prevention strategies for this patient population.

2. Methods

2.1. Study Variables

This was a case-control study using data obtained from patient records at the Fistula Care Center at Bwaila Hospital in Malawi, a facility which primarily serves fistula patients but which also attends to patients with some other more common complications of labor, including perineal tears. The Fistula Care Center patient record database was created to capture information on patients with reported urine leakage associated with pregnancy or childbirth. Those with leakage arising from VVF underwent one or more fistula closures or repair surgeries. The database contains patient demographic information, their past medical and social histories, information from a physical examination conducted by a doctor at the hospital, pre-operative, operative and post-operative notes and the information from up to three follow-ups that were conducted after surgery.

2.2. Statistical Analysis

We limited our analysis to women with VVF (study arm) and those with perineal tear only (control arm). Patients with perineal tear were used as the control group as the occurrence of perineal tear was presumed not to be dependent on healthcare access. Women with both conditions were excluded from the study. The exposure of interest was access to health care and the primary outcome (or cases) was VVF. Access to health care was defined as a composite variable using the following three indicators: (1) number of hours of walking to the hospital; (2) person assisting the delivery; and (3) receipt of antenatal care. Number of hours of walking to the hospital was categorized into: (i) ≤4 hours; (ii) >4 hours; or (iii) missing. Person assisting the delivery was categorized into: (i) formally trained professionals like doctors, nurses, midwives; (ii) untrained individuals like relatives or traditional birth attendants; or (iii) missing. Receipt of antenatal care was classified as (i) yes; (ii) no; and (iii) missing.

A missing value was assigned a score of 0 regardless of the variable; a score of 1, which indicated limited access, was assigned to the following: > 4 hours of walking to hospital; person other than doctors, nurses or midwives assisting the delivery and no access to antenatal care; and 2 for the best access to health care: <= 4 hours of walking to hospital; doctor, nurse or midwife assisting the delivery and access to antenatal care. We then created a composite variable called ‘Malawi Healthcare Access Index’ (MHAI) by summing the scores. The least possible score was a 0 for all missing values and the highest possible score was a 6, which denotes the best possible access to health care. A variable called ‘MHAI grade’ was created and a score of 4 or less was graded as ‘Insufficient’ category, which designated inadequate access to health care while a score of greater than four was designated as ‘Sufficient’ grade, which designated adequate access to health care. The indexing and grading was performed after removing records with missing information in any of the three exposure variables from the dataset.

We compared women who had VVF with women who had perineal tear based on socio-demographic and behavioral variables that included age, country, tribe, religion, place of residence, living arrangement, education, marital status, roof type of the house they lived in, occupation, HIV status, smoking, and alcohol consumption. Prevalence estimates for each socio-demographic and behavioral characteristic was computed and compared between cases (VVF) and control (perineal tear). We then conducted a similar bivariate comparison based on factors related to delivery that caused the leakage. These factors were maternal age at delivery, type of delivery (i.e. cesarean or vaginal), length of labor, intended place of delivery when the labor began, actual place of delivery, duration between labor onset and arrival at the hospital, number of hours of walking to the hospital, person attending the labor, person assisting the delivery, if the uterus was removed, condition of baby (i.e. alive or stillborn), and receipt of antenatal care. Pearson’s chi-square tests were conducted to detect differences between the strata of women (VVF vs. perineal tear) with respect to socio-demographic factors and factors related to delivery that was associated with the leakage. For variables containing more than 25% of the expected cell values of less than 5, we conducted Fisher’s exact test instead of Pearson’s chi-squared test.

We created an adjusted binomial logistic regression model to assess the association between MHAI grade and presence of VVF, with the reference group being women with perineal tear while adjusting for maternal place of residence, age, and marital status. All tests of hypothesis were two-tailed with a type 1-error rate at 5%. All statistical analyses were performed using R (version 3·5.1) and RStudio (Version 1·1·423).16

2.3. Ethical Approval

The Malawian National Health Science and Research Committee (CID 1116 Protocol number 929), and Institutional Review Board of Baylor College of Medicine (H37617) approved this study.

3. Results

3.1. Sociodemographic Characteristics

A total of 2,268 women were entered into the patient database from 2011 to 2019. After limiting our data to women with either VVF or perineal tear, and removal of the records with missing values, we were left with a total of 1,083 records. Among these, 1,046 (96.6%) women had a VVF occurring at the time of a delivery and 37 (3.4%) women had a perineal tear. There were 9 women who had both perineal tear and VVF and were excluded from the analysis. Table 1 summarizes results of comparison with respect to socio-demographic characteristics between women who developed VVF versus those with perineal tear. The vast majority (98.6%) of women with VVF were from rural areas, versus 75.7% in the control group. VVF patients were less likely to be married than the perineal tear group (65.4% vs 83.8%), and were more likely to live in a house with a grass or no roof as opposed to metal, wood, cement roof (79.5% vs 56.8%). Over 91.3% of VVF patients were peasant farmers compared to 54.1% of control subjects. Nearly 90% of women with VVF had less than secondary education, contrasting with 65.4% of controls. About 6.3% of women with VVF were HIV positive compared with 10.8% of women with perineal tear.

Table 1

Comparison of selected socio-demographic characteristics of women hospitalized for VVF (vesicovaginal fistula) versus those with perineal tear

Socio Demographic Factors	Perineal Tear		VVF Because of Delivery
	Count	Percentage	Count	Percentage	p-value
	n=37	%=3.4	n=1046	%=96.6
Age group					0.0902
<20 years	2	5.4	97	9.3
20-29 years	12	32.4	295	28.2
30-39 years	16	43.2	290	27.7
>=40 years	7	18.9	364	34.8
Country					0.0037*
Malawi	27	73.0	682	65.2
Mozambique	0	0.0	139	13.3
Zambia	0	0.0	2	0.2
Don’t know/Missing	10	27.0	169	16.2
Tribe					0.1260*
Yao	1	2.7	131	12.5
Chewa	27	73.0	568	54.3
Lomwe	2	5.4	106	10.1
Tumbuka	2	5.4	124	11.9
Others	5	13.5	109	10.4
Don’t know/Missing	0	0.0	8	0.8
Religion					0.3200
Christian	35	94.6	871	83.3
Muslim or others	2	5.4	143	13.7
Don’t know/Missing	0	0.0	32	3.1
Residence					< 0.0001*
Urban	9	24.3	14	1.3
Rural	28	75.7	1031	98.6
Don’t know/Missing	0	0.0	1	0.1
Living arrangement					0.0886*
Living alone	3	8.1	158	15.1
Living with husband	31	83.8	673	64.3
Living with family/friend	3	8.1	214	20.5
Don’t know/Missing	0	0.0	1	0.1
Education					< 0.0001
Less than secondary	24	64.9	929	88.8
Secondary or more	13	35.1	115	11.0
Don’t know/Missing	0	0.0	2	0.2
Marital Status					0.0025*
Single/never married	2	5.4	14	1.3
Married	31	83.8	684	65.4
Separated/divorced/widowed	4	10.8	348	33.3
Roof Type					0.0008
Grass/none	21	56.8	832	79.5
Metal/wood/cement	16	43.2	214	20.5
Occupation					< 0.0001*
Peasant farmer	20	54.1	955	91.3
Commercial farmer	0	0.0	3	0.3
Student/pupil	0	0.0	9	0.9
Unemployed	1	2.7	9	0.9
Civil servant/teacher	3	8.1	1	0.1
Housewife/caretaker	9	24.3	13	1.2
Small business owner	4	10.8	52	5.0
Casual laborer	0	0.0	3	0.3
Don’t know/Missing	0	0.0	1	0.1
HIV Status					0.0789
Yes	4	10.8	66	6.3
No	33	89.2	899	85.9
Don’t know/Missing	0	0.0	81	7.7
Smoking					0.3730*
Yes	0	0.0	28	2.7
No	37	100.0	1018	97.3
Alcohol					0.4170*
Yes	0	0.0	44	4.2
No	37	100.0	1001	95.7
Don’t know/Missing	1	2.7	1	0.1

represents p-values from Fisher’s exact test. Otherwise p-values are obtained from Pearson’s chi-square test

Table 2 shows factors related to the delivery resulting in urinary leakage or perineal tear. VVF occurred in deliveries at extremes of reproductive age (<20, and over 40) over 55% of the time, while perineal tear occurred at these ages approximately 24% of the time. Women with VVF ended up requiring a cesarean section 43.4% of the time versus 8% of the time in the reference group. Over 70% of the women with VVF had labor that lasted more than 12 hours compared with 57% of women with perineal tear. More women in the VVF group than the reference group intended to deliver at a facility other than a hospital (69.5% vs 59.5%). In the VVF group, 15.8% of women ended up with a hysterectomy, compared with 2.7% of women with perineal tear. Before controlling for co-variables, both groups had a similar rate of living over 4 hours of walking distance from the closest hospital (13.5%), and similar rates of attendance at delivery by unskilled provider (21.6% vs 19.8%). Consistent with prior reports on birth outcomes of fistula patients, 81% of the women with VVF had a stillbirth compared with 16.2% of perineal tear patients. Interestingly, 16% of the women with perineal tear did not receive any antenatal care, which was higher than the VVF group of 12.4%.

Table 2

Demographic data for factors related to the delivery leading to vesicovaginal fistula (VVF) or perineal tear

Factors Associated with delivery that caused leakage	Perineal Tear		VVF Because of Delivery		p-value
	Count	Percentage	Count	Percentage
	n=37	%=3.4	n=1046	%=96.6
Age at delivery that caused leakage					<0.0001
<20 years	7	18.9	230	22.0
20-29 years	15	40.5	246	23.5
30-39 years	11	29.7	124	11.9
>=40 years	2	5.4	341	32.6
Don’t know/Missing	2	5.4	105	10.0
Type of delivery					<0.0001*
Vaginal	3	8.1	589	56.3
Cesarean section	34	91.9	454	43.4
Missing	0	0.0	3	0.3
Length of labor					0.0188*
<=12 hours	16	43.2	309	29.5
>12 hours	21	56.8	734	70.2
Missing	0	0.0	3	0.3
Place of delivery					<0.0001
Central hospital	2	5.4	67	6.4
District/Mission/Private hospital	17	45.9	690	66.0
Health center	10	27.0	156	14.9
Home/TBA	8	21.6	122	11.7
Other	0	0.0	11	1.1
Duration between labor onset and hospital arrival					0.5090
<=5 hours	22	59.5	622	59.5
>5 hours	7	18.9	280	26.8
Missing	8	21.6	144	13.8
Number of hours of walking to the hospital					<0.0001
<=4 hours	32	86.5	905	86.5
>4 hours	5	13.5	141	13.5
Place of intended delivery when labor began					0.1940
Central/District/Mission/Private hospital	15	40.5	319	30.5
Others	22	59.5	727	69.5
Person attending the labor					0.3850
MO/CO	0	0.0	51	4.9
Curse/midwife	29	78.4	788	75.3
Others	8	21.6	207	19.8
Person assisting the delivery					<0.0001
MO/CO	17	45.9	809	77.3
Nurse/midwife	12	32.4	104	9.9
Others	8	21.6	133	12.7
Removal of uterus					0.0170*
Yes	1	2.7	165	15.8
No	36	97.3	824	78.8
Missing	0	0.0	57	5.4
Condition of baby					<0.0001
Alive	28	75.7	194	18.5
Stillborn	9	24.3	852	81.5
Receipt of antenatal care					<0.0001
Yes	31	83.8	916	87.6
No	6	16.2	130	12.4

represents p-values from Fisher's exact test. Otherwise p-values are obtained from Pearson's chi-square test

3.2. Healthcare Access and VVF

Table 3 displays the results generated from the binomial logistic regression models examining the association between health care access using MHAI grade and likelihood of having a VVF while adjusting for place of residence, marital status and education. We found a statistically significant negative association between health care access and occurrence of VVF. That is, women who had ‘insufficient’ grade health care access had almost three times the likelihood (OR = 2.64, 95%CI = 1.07 – 6.03) of suffering from VVF as compared to women with ‘sufficient’ health care access. For the covariates, it was found that rural women were 8 times more likely to have a VVF as compared to their urban counterparts. Also, women with less than secondary education were 3.85 times as likely (95% CI= 1.66 – 8.49) to suffer from VVF as compared to those with more than secondary education. Unexpectedly, women who were married at the time of the inerview were more likely to have a VVF as compared to single or unmarried women.

Table 3

Adjusted binomial logistic regression model estimates to quantify the likelihood of VVF (vesicovaginal fistula) using the Malawi Healthcare access index (MHAI) as predictive marker of the association between VVF and MHAI with perineal tear used as the reference group

	OR	95% CI	p-value
Malawi Healthcare Access Index Grade
Sufficient	Reference
Insufficient	2.64	(1.07,6.03)	0.03
Residence
Urban	Reference
Rural	8.1	(3.47,18.24)	<0.0001
Marital Status
Single/never married	Reference
Married	4.37	(1.19,15.18)	0.02
Separated /divorced/widowed	5.79	(1.54,20.60)	0.01
Education
Secondary or more	Reference
Less than secondary	3.85	(1.66,8.49)	<0.0001

4. Discussion

4.1. Discussion

This study examined demographic factors of patients with obstetric VVF receiving care in Malawi compared to those in a reference group (perineal tear) and association of VVF with access to health care and found that women living in poverty in rural areas, with lower levels of education, and less access with essential health services were more likely to suffer from an obstetric VVF. Among the study population, obstetric VVF was more common in women from rural areas living in poor housing- as identified by roof type, who worked as peasant farmers, and those with less than secondary school education. These characteristics generally indicate extreme poverty among women in Malawi. Furthermore, VVF tended to occur in women at extremes of reproductive age. After controlling for covariables, VVF was significantly more likely in women with poor access to health care (living far from a health facility, no skilled provider at delivery, and no antenatal care). These findings highlight the marked disparities within the health care delivery system, evidenced by the fact that obstetric VVF is most likely to occur in the most vulnerable populations least equipped to deal with the resulting significant personal and health ramifications.

Though other studies have focused on physical and clinical factors including height, parity, weight of the baby, age of mother, and adequacy of pelvis in evaluating risk for obstetric VVF, we focused our analysis on demographic and health access measures.17,18 Compared to other studies looking at education, our findings were consistent that higher levels of education are protective against VVF formation.17 In addition, similar to past studies we found that factors contributing to delay in care during labor (distance from health facility, attempted delivery at home) were associated with higher incidence of VVF.19

4.2. Limitations

This study has some important limitations. Because the reference population, or number of patients with isolated perineal tears, for this study was so small given that the hospital from which the data were collected specializes in fistula care, it was not possible to achieve tight confidence intervals for association models. This database was mainly developed from the records of women with fistula and with small numbers of patients presenting solely with perineal tear and no VVF which made our reference group very small further affecting the association model. Further studies are needed to more clearly elucidate the true incidence of obstetric fistula to better inform the development and implementation of fistula prevention strategies. Furthermore as the push to expand access to basic obstetric services is underway, future studies should measure the impact that such efforts are having on obstetric fistula formation.

5. Conclusion and Global Health Implications

Illustrated by its nearly complete eradication in developed countries, obstetric VVF is a preventable complication of labor which results from women having inadequate access to essential maternal health services. Given the increasing number of obstetric VVF cases and the limited treatment centers, focus must be shifted from treatment of obstetric VVF to prevention. As current capacity to repair obstetric VVF is far below the incidence of VVF, the number of preventable fistula cases is rapidly increasing.20,21 It is imperative that strategies targeting the most vulnerable populations- those living in poverty, from rural regions, with low levels of education, far from adequate healthcare resources, must be implemented to reduce the likelihood of preventable, stigmatizing, and life-altering health outcome of obstetric VVF.

Obstetric vesicovaginal fistula (VVF) in Malawi is more common in women from rural areas, mothers delivering at extremes of age, those with less education, and women with long labor (>12 hours).

Obstetric vesicovaginal fistula (VVF) is most likely to happen to marginalized women who are least equipped to deal with the long term consequences of fistula formation.