| Literature DB >> 32122900 |
Alireza Eshaghi1, Sandra Zittermann1, Amrita Bharat2, Michael R Mulvey2, Vanessa G Allen1,3, Samir N Patel4,3.
Abstract
A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were genetically related to the Pakistan outbreak strain. The appearance of XDR typhoid cases in Ontario prompted a provincial wide alert to physicians to recommend treatment with carbapenems or azithromycin in suspected typhoid cases with travel history to Pakistan. © Crown copyright 2020.Entities:
Keywords: XDR; antibiotic resistance; ceftriaxone; extensively drug resistant; typhoid fever; whole genome
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Year: 2020 PMID: 32122900 PMCID: PMC7179602 DOI: 10.1128/AAC.02581-19
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191