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Literature DB >> 32122896

Insecticidal Activity of Doxycycline against the Common Bedbug.

Abstract

There is an ongoing need for safe and effective anti-bedbug compounds. Here, we tested the toxicity of three antimicrobial agents against bedbugs when administered orally. We reveal that doxycycline has direct insecticidal activity at 250 μg/ml (0.025%) that is particularly strong against immature bedbugs and appears to be independent of antimicrobial activity. Future studies to determine the mechanisms behind this property could be useful for the development of orally active insecticides or anti-bedbug therapeutics.

Entities: Chemical Disease Species

Keywords: Cimexzzm321990; bedbug; doxycycline; insecticidal; insecticide; toxicity

Mesh：

Substances：

Year: 2020 PMID： 32122896 PMCID： PMC7179621 DOI： 10.1128/AAC.00005-20

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

25 in total

1. A screen of pharmaceutical drugs for their ability to cause short-term morbidity and mortality in the common bed bug, Cimex lectularius L.

Authors: Johnathan M Sheele; Gale E Ridge; Wenjing Du; Nikhil Mallipeddi; Mayur Vallabhaneni
Journal: Parasitol Res Date: 2017-08-03 Impact factor: 2.289

2. Doxycycline kills human lice through its activity on their bacterial symbiont.

Authors: Abdoul Karim Sangaré; Amina Boutellis; Rezak Drali; Gilles Audoly; Pascal Weber; Jean Marc Rolain; Didier Raoult
Journal: Int J Antimicrob Agents Date: 2015-03-14 Impact factor: 5.283

3. Uncovering the hidden cost of bed bugs.

Authors: Samuel V Scarpino; Benjamin M Althouse
Journal: Proc Natl Acad Sci U S A Date: 2019-03-22 Impact factor: 11.205

4. Wolbachia pipientis growth kinetics and susceptibilities to 13 antibiotics determined by immunofluorescence staining and real-time PCR.

Authors: Florence Fenollar; Max Maurin; Didier Raoult
Journal: Antimicrob Agents Chemother Date: 2003-05 Impact factor: 5.191

1. A Comparative Study of Body Lice and Bed Bugs Reveals Factors Potentially Involved in Differential Vector Competence for the Relapsing Fever Spirochete Borrelia recurrentis.

Authors: Rashaun Potts; Jamie L Scholl; Lee A Baugh; Jose E Pietri
Journal: Infect Immun Date: 2022-04-06 Impact factor: 3.609

1 in total

Insecticidal Activity of Doxycycline against the Common Bedbug.

1. A screen of pharmaceutical drugs for their ability to cause short-term morbidity and mortality in the common bed bug, Cimex lectularius L.

2. Doxycycline kills human lice through its activity on their bacterial symbiont.

3. Uncovering the hidden cost of bed bugs.

4. Wolbachia pipientis growth kinetics and susceptibilities to 13 antibiotics determined by immunofluorescence staining and real-time PCR.

5. Wolbachia as a bacteriocyte-associated nutritional mutualist.

6. Effect of metronidazole on the intestinal microflora of the american cockroach, Periplaneta americana l.

7. Ivermectin causes Cimex lectularius (bedbug) morbidity and mortality.

8. Mental health effects from urban bed bug infestation (Cimex lectularius L.): a cross-sectional study.

9. Functional characterization of Aquaporin-like genes in the human bed bug Cimex lectularius.

10. Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides.

1. A Comparative Study of Body Lice and Bed Bugs Reveals Factors Potentially Involved in Differential Vector Competence for the Relapsing Fever Spirochete Borrelia recurrentis.