Ultimate fate of heart transplantation. Seven years survival in a dog.

The morphological study of a canine cardiac transplantation whose survival was 7 years, without treatment for 6 years, is described. The pathological examination demonstrated a right-side heart failure due to pulmonary stenosis. A histological study revealed marks of chronical rejection induced by vascular fibrosis and perivascular infiltration of lymphocytes. This unusual kind of tolerance could be induced by donor blood transfusion at the time of transplantation.