Literature DB >> 32121394

The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment.

Elodie Renaude1,2, Marie Kroemer1,3, Romain Loyon1,2,4, Delphine Binda1,2, Christophe Borg1,2,4, Michaël Guittaut1,5, Eric Hervouet1,5,6, Paul Peixoto1,6.   

Abstract

Th17 cells represent a subset of CD4+ T cells characterized by the master transcription factor RORγt and the production of IL-17. Epigenetic modifications such as post-translational histone modifications and DNA methylation play a key role in Th17 cell differentiation and high plasticity. Th17 cells are highly recruited in many types of cancer and can be associated with good or bad prognosis. Here, we will review the remodeling of the epigenome induced by the tumor microenvironment, which may explain Th17 cell predominance. We will also discuss the promising treatment perspectives of molecules targeting epigenetic enzymes to remodel a Th17-enriched tumor microenvironment.

Entities:  

Keywords:  TIL; Th17 cells; epigenetic modifications; tumor microenvironment

Year:  2020        PMID： 32121394     DOI： 10.3390/ijms21051673

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  9 in total

1.  Investigation of the prognostic value of CD4 T cell subsets expanded from tumor-infiltrating lymphocytes of colorectal cancer liver metastases.

Authors:  Marie Kroemer; Celia Turco; Laurie Spehner; Julien Viot; Idir Idirène; Adeline Bouard; Elodie Renaude; Marina Deschamps; Yann Godet; Olivier Adotévi; Samuel Limat; Bruno Heyd; Marine Jary; Romain Loyon; Christophe Borg
Journal:  J Immunother Cancer       Date:  2020-11       Impact factor: 13.751

Review 2.  CD4+ T Cells: Multitasking Cells in the Duty of Cancer Immunotherapy.

Authors:  Jennifer R Richardson; Anna Schöllhorn; Cécile Gouttefangeas; Juliane Schuhmacher
Journal:  Cancers (Basel)       Date:  2021-02-03       Impact factor: 6.639

3.  6,7,4'-Trihydroxyflavanone Protects against Dextran Sulfate Sodium-Induced Colitis by Regulating the Activity of T Cells and Colon Cells In Vivo.

Authors:  Hyun-Su Lee; Gil-Saeng Jeong
Journal:  Int J Mol Sci       Date:  2021-02-19       Impact factor: 5.923

Review 4.  The Role of Decorin and Biglycan Signaling in Tumorigenesis.

Authors:  Valentina Diehl; Lisa Sophie Huber; Jonel Trebicka; Malgorzata Wygrecka; Renato V Iozzo; Liliana Schaefer
Journal:  Front Oncol       Date:  2021-11-30       Impact factor: 6.244

Review 5.  Epigenetic modulation of antitumor immunity for improved cancer immunotherapy.

Authors:  Enyong Dai; Zhi Zhu; Shudipto Wahed; Zhaoxia Qu; Walter J Storkus; Zong Sheng Guo
Journal:  Mol Cancer       Date:  2021-12-20       Impact factor: 41.444

6.  Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3+ and CD8+ T cell density and predict prognosis in hepatocellular carcinoma.

Authors:  Lorenzo Nicolè; Tiziana Sanavia; Rocco Cappellesso; Valeria Maffeis; Jun Akiba; Akihiko Kawahara; Yoshiki Naito; Claudia Maria Radu; Paolo Simioni; Davide Serafin; Giuliana Cortese; Maria Guido; Giacomo Zanus; Hirohisa Yano; Ambrogio Fassina
Journal:  J Immunother Cancer       Date:  2022-03       Impact factor: 13.751

Review 7.  Epigenetic regulation and T-cell responses in endometriosis - something other than autoimmunity.

Authors:  Dariusz Szukiewicz
Journal:  Front Immunol       Date:  2022-07-22       Impact factor: 8.786

8.  The expression and methylation of PITX genes is associated with the prognosis of head and neck squamous cell carcinoma.

Authors:  Yaqiong Zhao; Jie Zhao; Mengmei Zhong; Qian Zhang; Fei Yan; Yunzhi Feng; Yue Guo
Journal:  Front Genet       Date:  2022-09-20       Impact factor: 4.772

9.  Comprehensive profiling of immune-related genes in soft tissue sarcoma patients.

Authors:  Chuan Hu; Bo Chen; Zhangheng Huang; Chuan Liu; Lin Ye; Cailin Wang; Yuexin Tong; Jiaxin Yang; Chengliang Zhao
Journal:  J Transl Med       Date:  2020-09-01       Impact factor: 5.531
  9 in total

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