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Literature DB >> 32121253

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases.

Madhulika Tripathi¹, Paul Michael Yen¹, Brijesh Kumar Singh¹.

Abstract

The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.

Entities: Chemical Disease Gene Species

Keywords: Estrogen-related receptor alpha; adaptive thermogenesis; adipogenesis; metabolic diseases; mitochondrial turnover; mitophagy; non-alcoholic fatty liver disease (NAFLD)

Year: 2020 PMID： 32121253 DOI： 10.3390/ijms21051645

Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923

14 in total

1. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.

Authors: Shweta Ramdas; Jonathan Judd; Sarah E Graham; Stavroula Kanoni; Yuxuan Wang; Ida Surakka; Brandon Wenz; Shoa L Clarke; Alessandra Chesi; Andrew Wells; Konain Fatima Bhatti; Sailaja Vedantam; Thomas W Winkler; Adam E Locke; Eirini Marouli; Greg J M Zajac; Kuan-Han H Wu; Ioanna Ntalla; Qin Hui; Derek Klarin; Austin T Hilliard; Zeyuan Wang; Chao Xue; Gudmar Thorleifsson; Anna Helgadottir; Daniel F Gudbjartsson; Hilma Holm; Isleifur Olafsson; Mi Yeong Hwang; Sohee Han; Masato Akiyama; Saori Sakaue; Chikashi Terao; Masahiro Kanai; Wei Zhou; Ben M Brumpton; Humaira Rasheed; Aki S Havulinna; Yogasudha Veturi; Jennifer Allen Pacheco; Elisabeth A Rosenthal; Todd Lingren; QiPing Feng; Iftikhar J Kullo; Akira Narita; Jun Takayama; Hilary C Martin; Karen A Hunt; Bhavi Trivedi; Jeffrey Haessler; Franco Giulianini; Yuki Bradford; Jason E Miller; Archie Campbell; Kuang Lin; Iona Y Millwood; Asif Rasheed; George Hindy; Jessica D Faul; Wei Zhao; David R Weir; Constance Turman; Hongyan Huang; Mariaelisa Graff; Ananyo Choudhury; Dhriti Sengupta; Anubha Mahajan; Michael R Brown; Weihua Zhang; Ketian Yu; Ellen M Schmidt; Anita Pandit; Stefan Gustafsson; Xianyong Yin; Jian'an Luan; Jing-Hua Zhao; Fumihiko Matsuda; Hye-Mi Jang; Kyungheon Yoon; Carolina Medina-Gomez; Achilleas Pitsillides; Jouke Jan Hottenga; Andrew R Wood; Yingji Ji; Zishan Gao; Simon Haworth; Ruth E Mitchell; Jin Fang Chai; Mette Aadahl; Anne A Bjerregaard; Jie Yao; Ani Manichaikul; Wen-Jane Lee; Chao Agnes Hsiung; Helen R Warren; Julia Ramirez; Jette Bork-Jensen; Line L Kårhus; Anuj Goel; Maria Sabater-Lleal; Raymond Noordam; Pala Mauro; Floris Matteo; Aaron F McDaid; Pedro Marques-Vidal; Matthias Wielscher; Stella Trompet; Naveed Sattar; Line T Møllehave; Matthias Munz; Lingyao Zeng; Jianfeng Huang; Bin Yang; Alaitz Poveda; Azra Kurbasic; Sebastian Schönherr; Lukas Forer; Markus Scholz; Tessel E Galesloot; Jonathan P Bradfield; Sanni E Ruotsalainen; E Warwick Daw; Joseph M Zmuda; Jonathan S Mitchell; Christian Fuchsberger; Henry Christensen; Jennifer A Brody; Phuong Le; Mary F Feitosa; Mary K Wojczynski; Daiane Hemerich; Michael Preuss; Massimo Mangino; Paraskevi Christofidou; Niek Verweij; Jan W Benjamins; Jorgen Engmann; Tsao L Noah; Anurag Verma; Roderick C Slieker; Ken Sin Lo; Nuno R Zilhao; Marcus E Kleber; Graciela E Delgado; Shaofeng Huo; Daisuke D Ikeda; Hiroyuki Iha; Jian Yang; Jun Liu; Ayşe Demirkan; Hampton L Leonard; Jonathan Marten; Carina Emmel; Börge Schmidt; Laura J Smyth; Marisa Cañadas-Garre; Chaolong Wang; Masahiro Nakatochi; Andrew Wong; Nina Hutri-Kähönen; Xueling Sim; Rui Xia; Alicia Huerta-Chagoya; Juan Carlos Fernandez-Lopez; Valeriya Lyssenko; Suraj S Nongmaithem; Alagu Sankareswaran; Marguerite R Irvin; Christopher Oldmeadow; Han-Na Kim; Seungho Ryu; Paul R H J Timmers; Liubov Arbeeva; Rajkumar Dorajoo; Leslie A Lange; Gauri Prasad; Laura Lorés-Motta; Marc Pauper; Jirong Long; Xiaohui Li; Elizabeth Theusch; Fumihiko Takeuchi; Cassandra N Spracklen; Anu Loukola; Sailalitha Bollepalli; Sophie C Warner; Ya Xing Wang; Wen B Wei; Teresa Nutile; Daniela Ruggiero; Yun Ju Sung; Shufeng Chen; Fangchao Liu; Jingyun Yang; Katherine A Kentistou; Bernhard Banas; Anna Morgan; Karina Meidtner; Lawrence F Bielak; Jennifer A Smith; Prashantha Hebbar; Aliki-Eleni Farmaki; Edith Hofer; Maoxuan Lin; Maria Pina Concas; Simona Vaccargiu; Peter J van der Most; Niina Pitkänen; Brian E Cade; Sander W van der Laan; Kumaraswamy Naidu Chitrala; Stefan Weiss; Amy R Bentley; Ayo P Doumatey; Adebowale A Adeyemo; Jong Young Lee; Eva R B Petersen; Aneta A Nielsen; Hyeok Sun Choi; Maria Nethander; Sandra Freitag-Wolf; Lorraine Southam; Nigel W Rayner; Carol A Wang; Shih-Yi Lin; Jun-Sing Wang; Christian Couture; Leo-Pekka Lyytikäinen; Kjell Nikus; Gabriel Cuellar-Partida; Henrik Vestergaard; Bertha Hidalgo; Olga Giannakopoulou; Qiuyin Cai; Morgan O Obura; Jessica van Setten; Karen Y He; Hua Tang; Natalie Terzikhan; Jae Hun Shin; Rebecca D Jackson; Alexander P Reiner; Lisa Warsinger Martin; Zhengming Chen; Liming Li; Takahisa Kawaguchi; Joachim Thiery; Joshua C Bis; Lenore J Launer; Huaixing Li; Mike A Nalls; Olli T Raitakari; Sahoko Ichihara; Sarah H Wild; Christopher P Nelson; Harry Campbell; Susanne Jäger; Toru Nabika; Fahd Al-Mulla; Harri Niinikoski; Peter S Braund; Ivana Kolcic; Peter Kovacs; Tota Giardoglou; Tomohiro Katsuya; Dominique de Kleijn; Gert J de Borst; Eung Kweon Kim; Hieab H H Adams; M Arfan Ikram; Xiaofeng Zhu; Folkert W Asselbergs; Adriaan O Kraaijeveld; Joline W J Beulens; Xiao-Ou Shu; Loukianos S Rallidis; Oluf Pedersen; Torben Hansen; Paul Mitchell; Alex W Hewitt; Mika Kähönen; Louis Pérusse; Claude Bouchard; Anke Tönjes; Yii-Der Ida Chen; Craig E Pennell; Trevor A Mori; Wolfgang Lieb; Andre Franke; Claes Ohlsson; Dan Mellström; Yoon Shin Cho; Hyejin Lee; Jian-Min Yuan; Woon-Puay Koh; Sang Youl Rhee; Jeong-Taek Woo; Iris M Heid; Klaus J Stark; Martina E Zimmermann; Henry Völzke; Georg Homuth; Michele K Evans; Alan B Zonderman; Ozren Polasek; Gerard Pasterkamp; Imo E Hoefer; Susan Redline; Katja Pahkala; Albertine J Oldehinkel; Harold Snieder; Ginevra Biino; Reinhold Schmidt; Helena Schmidt; Stefania Bandinelli; George Dedoussis; Thangavel Alphonse Thanaraj; Patricia A Peyser; Norihiro Kato; Matthias B Schulze; Giorgia Girotto; Carsten A Böger; Bettina Jung; Peter K Joshi; David A Bennett; Philip L De Jager; Xiangfeng Lu; Vasiliki Mamakou; Morris Brown; Mark J Caulfield; Patricia B Munroe; Xiuqing Guo; Marina Ciullo; Jost B Jonas; Nilesh J Samani; Jaakko Kaprio; Päivi Pajukanta; Teresa Tusié-Luna; Carlos A Aguilar-Salinas; Linda S Adair; Sonny Augustin Bechayda; H Janaka de Silva; Ananda R Wickremasinghe; Ronald M Krauss; Jer-Yuarn Wu; Wei Zheng; Anneke I den Hollander; Dwaipayan Bharadwaj; Adolfo Correa; James G Wilson; Lars Lind; Chew-Kiat Heng; Amanda E Nelson; Yvonne M Golightly; James F Wilson; Brenda Penninx; Hyung-Lae Kim; John Attia; Rodney J Scott; D C Rao; Donna K Arnett; Mark Walker; Laura J Scott; Heikki A Koistinen; Giriraj R Chandak; Josep M Mercader; Clicerio Gonzalez Villalpando; 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Zoltan Kutalik; Cucca Francesco; Dennis O Mook-Kanamori; Ko Willems van Dijk; Hugh Watkins; David P Strachan; Niels Grarup; Peter Sever; Neil Poulter; Wayne Huey-Herng Sheu; Jerome I Rotter; Thomas M Dantoft; Fredrik Karpe; Matt J Neville; Nicholas J Timpson; Ching-Yu Cheng; Tien-Yin Wong; Chiea Chuen Khor; Hengtong Li; Charumathi Sabanayagam; Annette Peters; Christian Gieger; Andrew T Hattersley; Nancy L Pedersen; Patrik K E Magnusson; Dorret I Boomsma; Eco J C de Geus; L Adrienne Cupples; Joyce B J van Meurs; Arfan Ikram; Mohsen Ghanbari; Penny Gordon-Larsen; Wei Huang; Young Jin Kim; Yasuharu Tabara; Nicholas J Wareham; Claudia Langenberg; Eleftheria Zeggini; Jaakko Tuomilehto; Johanna Kuusisto; Markku Laakso; Erik Ingelsson; Goncalo Abecasis; John C Chambers; Jaspal S Kooner; Paul S de Vries; Alanna C Morrison; Scott Hazelhurst; Michèle Ramsay; Kari E North; Martha Daviglus; Peter Kraft; Nicholas G Martin; John B Whitfield; Shahid Abbas; Danish Saleheen; Robin G Walters; Michael V Holmes; Corri Black; Blair H Smith; Aris Baras; Anne E Justice; Julie E Buring; Paul M Ridker; Daniel I Chasman; Charles Kooperberg; Gen Tamiya; Masayuki Yamamoto; David A van Heel; Richard C Trembath; Wei-Qi Wei; Gail P Jarvik; Bahram Namjou; M Geoffrey Hayes; Marylyn D Ritchie; Pekka Jousilahti; Veikko Salomaa; Kristian Hveem; Bjørn Olav Åsvold; Michiaki Kubo; Yoichiro Kamatani; Yukinori Okada; Yoshinori Murakami; Bong-Jo Kim; Unnur Thorsteinsdottir; Kari Stefansson; Jifeng Zhang; Y Eugene Chen; Yuk-Lam Ho; Julie A Lynch; Philip S Tsao; Kyong-Mi Chang; Kelly Cho; Christopher J O'Donnell; John M Gaziano; Peter Wilson; Karen L Mohlke; Timothy M Frayling; Joel N Hirschhorn; Sekar Kathiresan; Michael Boehnke; Pradeep Natarajan; Yan V Sun; Andrew P Morris; Panos Deloukas; Gina Peloso; Themistocles L Assimes; Cristen J Willer; Xiang Zhu; Christopher D Brown
Journal: Am J Hum Genet Date: 2022-08-04 Impact factor: 11.043

2. Cell-Based Assays to Identify ERR and ERR/PGC Modulators.

Authors: Caitlin Lynch; Jinghua Zhao; Menghang Xia
Journal: Methods Mol Biol Date: 2022

3. A Global Vista of the Epigenomic State of the Mouse Submandibular Gland.

Authors: C Gluck; S Min; A Oyelakin; M Che; E Horeth; E A C Song; J Bard; N Lamb; S Sinha; R A Romano
Journal: J Dent Res Date: 2021-05-12 Impact factor: 6.116

4. Shared aspects of mRNA expression associated with oocyte maturation failure in humans and rhesus monkeys indicating compromised oocyte quality.

Authors: Meghan L Ruebel; Filippo Zambelli; Peter Z Schall; Montserrat Barragan; Catherine A VandeVoort; Rita Vassena; Keith E Latham
Journal: Physiol Genomics Date: 2021-02-08 Impact factor: 3.107

10. Declined expressions of vast mitochondria-related genes represented by CYCS and transcription factor ESRRA in skeletal muscle aging.

Authors: Jingbao Kan; Yifang Hu; Yaoqi Ge; WenSong Zhang; Shan Lu; Cuiping Zhao; Rihua Zhang; Yun Liu
Journal: Bioengineered Date: 2021-12 Impact factor: 3.269

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases.

1. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.

2. Cell-Based Assays to Identify ERR and ERR/PGC Modulators.

3. A Global Vista of the Epigenomic State of the Mouse Submandibular Gland.

4. Shared aspects of mRNA expression associated with oocyte maturation failure in humans and rhesus monkeys indicating compromised oocyte quality.

5. Discovery of a Novel Class of ERRα Agonists.

6. Transcriptomic analysis of the trade-off between endurance and burst-performance in the frog Xenopus allofraseri.

Review 7. Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action.

Review 8. Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics.

Review 9. COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm.

10. Declined expressions of vast mitochondria-related genes represented by CYCS and transcription factor ESRRA in skeletal muscle aging.