Literature DB >> 32120072

Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line.

Fatima Ezzahra Bennani1, Latifa Doudach2, Yahia Cherrah3, Youssef Ramli4, Khalid Karrouchi4, M'hammed Ansar4, My El Abbes Faouzi3.   

Abstract

Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C3H3N2H.The presence of this nucleus in pharmacological agents of various therapeutic categories gifts a broad spectrum of biological activities and pharmaceuticals that contain pyrazole like celecoxib (anti-inflammatory), CDPPB (antipsychotic), Rimonabant (anti-obesity), Difenamizole, (Analgesic), Betazole (H2 receptor agonist), Fezolamide (Antidepressant), etc… The pharmacological potential of the pyrazole fraction is proved in many publication where they synthesized and evaluated pyrazoles against several biological agents. The aim of this article review is to survey recent works linking pyrazole structures to anticancer activities corresponding to 9 different type of cancer.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Anticancer activities; Cancer cell line; Pyrazole derivatives; Synthesis

Mesh：

Substances：

Year:  2019        PMID： 32120072     DOI： 10.1016/j.bioorg.2019.103470

Source DB:  PubMed          Journal:  Bioorg Chem        ISSN： 0045-2068            Impact factor:   5.275


  15 in total

Review 1.  Structure-Activity Relationship of Benzofuran Derivatives with Potential Anticancer Activity.

Authors:  Joviana Farhat; Lara Alzyoud; Mohammad Alwahsh; Basem Al-Omari
Journal:  Cancers (Basel)       Date:  2022-04-28       Impact factor: 6.575

2.  Quantitative and Qualitative Analysis of the Anti-Proliferative Potential of the Pyrazole Scaffold in the Design of Anticancer Agents.

Authors:  George Mihai Nitulescu
Journal:  Molecules       Date:  2022-05-20       Impact factor: 4.927

3.  Novel Pyran-Linked Phthalazinone-Pyrazole Hybrids: Synthesis, Cytotoxicity Evaluation, Molecular Modeling, and Descriptor Studies.

Authors:  M Shaheer Malik; Basim H Asghar; Riyaz Syed; Reem I Alsantali; Moataz Morad; Hatem M Altass; Ziad Moussa; Ismail I Althagafi; Rabab S Jassas; Saleh A Ahmed
Journal:  Front Chem       Date:  2021-05-24       Impact factor: 5.221

4.  Novel pyrazoles as potent growth inhibitors of staphylococci, enterococci and Acinetobacter baumannii bacteria.

Authors:  Ibrahim Alkhaibari; Hansa Raj Kc; Duminduni H Angappulige; David Gilmore; Mohammad A Alam
Journal:  Future Med Chem       Date:  2021-12-08       Impact factor: 3.808

5.  Novel piperazine-chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation.

Authors:  Marwa F Ahmed; Eman Y Santali; Radwan El-Haggar
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

Review 6.  Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery.

Authors:  Vuyolwethu Khwaza; Sithenkosi Mlala; Opeoluwa O Oyedeji; Blessing A Aderibigbe
Journal:  Molecules       Date:  2021-04-21       Impact factor: 4.411

7.  Coordination complexes constructed from pyrazole-acetamide and pyrazole-quinoxaline: effect of hydrogen bonding on the self-assembly process and antibacterial activity.

Authors:  Karim Chkirate; Khalid Karrouchi; Hind Chakchak; Joel T Mague; Smaail Radi; N N Adarsh; Weiyang Li; Ahmed Talbaoui; El Mokhtar Essassi; Yann Garcia
Journal:  RSC Adv       Date:  2022-02-14       Impact factor: 3.361

Review 8.  Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations.

Authors:  Rafael Fernades Costa; Larissa Córdova Turones; Keilah Valéria Naves Cavalcante; Ismael Aureliano Rosa Júnior; Carlos Henrique Xavier; Lucimar Pinheiro Rosseto; Hamilton Barbosa Napolitano; Patrícia Ferreira da Silva Castro; Marcos Luiz Ferreira Neto; Gustavo Mota Galvão; Ricardo Menegatti; Gustavo Rodrigues Pedrino; Elson Alves Costa; José Luis Rodrigues Martins; James Oluwagbamigbe Fajemiroye
Journal:  Front Pharmacol       Date:  2021-05-10       Impact factor: 5.810

9.  Anticolon Cancer Properties of Pyrazole Derivatives Acting through Xanthine Oxidase Inhibition.

Authors:  Abdulrhman Alsayari; Yahya I Asiri; Abdullatif Bin Muhsinah; Mohd Zaheen Hassan
Journal:  J Oncol       Date:  2021-07-05       Impact factor: 4.375

Review 10.  Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry.

Authors:  Chiara Brullo; Federica Rapetti; Olga Bruno
Journal:  Molecules       Date:  2020-07-29       Impact factor: 4.411
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