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Literature DB >> 32119837

Epigenetics/epigenomics of triterpenoids in cancer prevention and in health.

Shanyi Li¹, Hsiao-Chen Dina Kuo², Ran Yin¹, Renyi Wu¹, Xia Liu¹, Lujing Wang², Rasika Hudlikar¹, Rebecca Mary Peter², Ah-Ng Kong³.

Abstract

Triterpenoids are a powerful group of phytochemicals derived from plant foods and herbs. Many reports have shown that they possess chemopreventive and chemotherapeutic effects not only in cell lines and animal models but also in clinical trials. Because epigenetic changes could potentially occur in the early stages of carcinogenesis preceding genetic mutations, epigenetics are considered promising targets in early interventions against cancer using epigenetic bioactive substances. The biological properties of triterpenoids in cancer prevention and in health have multiple mechanisms, including antioxidant and anti-inflammatory activities, cell cycle regulation, as well as epigenetic/epigenomic regulation. In this review, we will discuss and summarize the latest advances in the study of the pharmacological effects of triterpenoids in cancer chemoprevention and in health, including the epigenetic machinery.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Cancer; Chemoprevention; Epigenetics; Phytochemicals; Triterpenoids

Mesh：

Substances：

Year: 2020 PMID： 32119837 PMCID： PMC7174132 DOI： 10.1016/j.bcp.2020.113890

Source DB: PubMed Journal: Biochem Pharmacol ISSN： 0006-2952 Impact factor: 5.858

135 in total

1. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements.

Authors: Allen S Yang; Marcos R H Estécio; Ketan Doshi; Yutaka Kondo; Eloiza H Tajara; Jean-Pierre J Issa
Journal: Nucleic Acids Res Date: 2004-02-18 Impact factor: 16.971

2. Oleanolic acid prevents glucocorticoid-induced hypertension in rats.

Authors: Sagar S Bachhav; Savita D Patil; Mukesh S Bhutada; Sanjay J Surana
Journal: Phytother Res Date: 2011-02-24 Impact factor: 5.878

Review 3. Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention.

Authors: Samriddhi Shukla; Syed M Meeran; Santosh K Katiyar
Journal: Cancer Lett Date: 2014-09-16 Impact factor: 8.679

4. Extract of Ilex rotunda Thunb alleviates experimental colitis-associated cancer via suppressing inflammation-induced miR-31-5p/YAP overexpression.

Authors: Gang Chen; Yueqing Han; Yuan Feng; Aiping Wang; Xuezheng Li; Song Deng; Lin Zhang; Jiao Xiao; Yanwu Li; Ning Li
Journal: Phytomedicine Date: 2019-04-30 Impact factor: 5.340

5. Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.

Authors: Ping Wang; Stacy Ownby; Zhizhen Zhang; Wei Yuan; Shiyou Li
Journal: Bioorg Med Chem Lett Date: 2010-03-15 Impact factor: 2.823

6. Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects.

Authors: Xin Wang; Rui Liu; Wei Zhang; Xiaodi Zhang; Nai Liao; Zhao Wang; Wenli Li; Xujun Qin; Chunxu Hai
Journal: Mol Cell Endocrinol Date: 2013-06-18 Impact factor: 4.102

Review 7. Epigenetics: definition, mechanisms and clinical perspective.

Authors: Cathérine Dupont; D Randall Armant; Carol A Brenner
Journal: Semin Reprod Med Date: 2009-08-26 Impact factor: 1.303

8. How many cancer cases and deaths are potentially preventable? Estimates for Australia in 2013.

Authors: Louise F Wilson; Annika Antonsson; Adele C Green; Susan J Jordan; Bradley J Kendall; Christina M Nagle; Rachel E Neale; Catherine M Olsen; Penelope M Webb; David C Whiteman
Journal: Int J Cancer Date: 2017-10-26 Impact factor: 7.396

9. Epigenetic Gene Regulation by Dietary Compounds in Cancer Prevention.

Authors: McKale Montgomery; Aishwarya Srinivasan
Journal: Adv Nutr Date: 2019-11-01 Impact factor: 8.701

10. Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells.

Authors: Seong-Hoon Kim; Hye Guk Ryu; Juhyun Lee; Joon Shin; Amaravadhi Harikishore; Hoe-Yune Jung; Hoe-Youn Jung; Ye Seul Kim; Ha-Na Lyu; Eunji Oh; Nam-In Baek; Kwan-Yong Choi; Ho Sup Yoon; Kyong-Tai Kim
Journal: Sci Rep Date: 2015-09-28 Impact factor: 4.379

12 in total

Review 1. Molecular Mechanism of Anti-Colorectal Cancer Effect of Hedyotis diffusa Willd and Its Extracts.

Authors: Zihong Wu; Bei Yin; Fengming You
Journal: Front Pharmacol Date: 2022-06-02 Impact factor: 5.988

Review 2. Redox signaling, mitochondrial metabolism, epigenetics and redox active phytochemicals.

Authors: Renyi Wu; Shanyi Li; Rasika Hudlikar; Lujing Wang; Ahmad Shannar; Rebecca Peter; Pochung Jordan Chou; Hsiao-Chen Dina Kuo; Zhigang Liu; Ah-Ng Kong
Journal: Free Radic Biol Med Date: 2020-12-24 Impact factor: 7.376

Review 3. Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer.

Authors: Qiang Wang; Wei Geng; Huimin Guo; Zhangding Wang; Kaiyue Xu; Chen Chen; Shouyu Wang
Journal: J Hematol Oncol Date: 2020-05-19 Impact factor: 17.388

Review 4. Targeting Mitochondrial Metabolism in Prostate Cancer with Triterpenoids.

Authors: Kenza Mamouni; Georgios Kallifatidis; Bal L Lokeshwar
Journal: Int J Mol Sci Date: 2021-02-28 Impact factor: 5.923

Review 5. Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review.

Authors: Sareh Kamran; Ajantha Sinniah; Mahfoudh A M Abdulghani; Mohammed Abdullah Alshawsh
Journal: Cancers (Basel) Date: 2022-02-22 Impact factor: 6.639

6. Simultaneous Determination and Pharmacokinetics Study of Three Triterpenes from Sanguisorba officinalis L. in Rats by UHPLC-MS/MS.

Authors: Fanshu Wei; Chunjuan Yang; Lihong Wu; Jiahui Sun; Zhenyue Wang; Zhibin Wang
Journal: Molecules Date: 2022-08-24 Impact factor: 4.927