Luciano Inácio Mariano1,2, Paulo Caramelli1,3, Henrique Cerqueira Guimarães1, Leandro Boson Gambogi1, Millena Vieira Brandão Moura2, Mônica Sanches Yassuda4,5, Antônio Lúcio Teixeira6,7, Leonardo Cruz de Souza1,2,3. 1. Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Instituto de Ciências Biológicas, Pampulha, Belo Horizonte, Minas Gerais (MG), Brazil. 2. Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil. 3. Departamento de Clínica Médica, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil. 4. Grupo de Neurologia Cognitiva e do Comportamento (GNCC), Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Cerqueira César, São Paulo, SP, Brazil. 5. Programa de Pós-Graduação em Gerontologia, Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, São Paulo, SP, Brazil. 6. Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. 7. Santa Casa BH Ensino e Pesquisa, Santa Efigênia, Belo Horizonte, MG, Brazil.
Abstract
BACKGROUND: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) share cognitive and behavioral symptoms, such as apathy. Social cognition measurements are useful in distinguishing bvFTD from AD, but their accuracies may be affected by apathy. OBJECTIVE: To investigate whether social cognition measurements can distinguish bvFTD from either apathetic or non-apathetic AD patients. METHODS: Three groups of participants were enrolled in the present study: bvFTD (n = 22), AD (n = 20), and healthy controls (HC, n = 23). The AD group was divided into apathetic (n = 10) and non-apathetic (n = 10). All subjects underwent comprehensive neuropsychological examination, including the short version of the Social and Emotional Assessment (Mini-SEA), which comprises the facial emotion recognition test and the faux-pas recognition test (Faux-Pas Test). Apathy was assessed according to the Starkstein's Apathy (SA) Scale. RESULTS: The bvFTD and AD groups did not differ on global cognitive efficiency and on executive functions. In comparison to the whole AD group, bvFTD displayed lower Faux-Pas Test and Mini-SEA scores. Both AD subgroups, apathetic or non-apathetic, exhibited similar performance on all social cognition measurements. In comparison to either apathetic AD or non-apathetic AD, bvFTD patients underperformed on the Faux-Pas Test and on the Mini-SEA. The area under the curve values for the Mini-SEA total score were 0.87 (bvFTD versus AD), 0.90 (bvFTD versus apathetic AD), and 0.83 (bvFTD versus non-apathetic AD). CONCLUSION: Social cognition tests provide accurate distinction between bvFTD against either apathetic AD or non-apathetic AD. Social cognition measurements did not correlate with apathy severity.
BACKGROUND:Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) share cognitive and behavioral symptoms, such as apathy. Social cognition measurements are useful in distinguishing bvFTD from AD, but their accuracies may be affected by apathy. OBJECTIVE: To investigate whether social cognition measurements can distinguish bvFTD from either apathetic or non-apathetic ADpatients. METHODS: Three groups of participants were enrolled in the present study: bvFTD (n = 22), AD (n = 20), and healthy controls (HC, n = 23). The AD group was divided into apathetic (n = 10) and non-apathetic (n = 10). All subjects underwent comprehensive neuropsychological examination, including the short version of the Social and Emotional Assessment (Mini-SEA), which comprises the facial emotion recognition test and the faux-pas recognition test (Faux-Pas Test). Apathy was assessed according to the Starkstein's Apathy (SA) Scale. RESULTS: The bvFTD and AD groups did not differ on global cognitive efficiency and on executive functions. In comparison to the whole AD group, bvFTD displayed lower Faux-Pas Test and Mini-SEA scores. Both AD subgroups, apathetic or non-apathetic, exhibited similar performance on all social cognition measurements. In comparison to either apathetic AD or non-apathetic AD, bvFTD patients underperformed on the Faux-Pas Test and on the Mini-SEA. The area under the curve values for the Mini-SEA total score were 0.87 (bvFTD versus AD), 0.90 (bvFTD versus apathetic AD), and 0.83 (bvFTD versus non-apathetic AD). CONCLUSION: Social cognition tests provide accurate distinction between bvFTD against either apathetic AD or non-apathetic AD. Social cognition measurements did not correlate with apathy severity.
Entities:
Keywords:
Alzheimer’s disease; apathy; frontotemporal dementia; social cognition
Authors: Fernando Henríquez; Victoria Cabello; Sandra Baez; Leonardo Cruz de Souza; Patricia Lillo; David Martínez-Pernía; Loreto Olavarría; Teresa Torralva; Andrea Slachevsky Journal: Front Neurol Date: 2022-02-16 Impact factor: 4.003
Authors: Claudia Duran-Aniotz; Paulina Orellana; Tomas Leon Rodriguez; Fernando Henriquez; Victoria Cabello; María F Aguirre-Pinto; Tamara Escobedo; Leonel T Takada; Stefanie D Pina-Escudero; Oscar Lopez; Jennifer S Yokoyama; Agustin Ibanez; Mario A Parra; Andrea Slachevsky Journal: Front Neurol Date: 2021-06-24 Impact factor: 4.003