Acute hepatic failure precipitated in a patient with subclinical liver disease by vibrionic and clostridial septicemia.

A case of fatal septicemia caused by Vibrio vulnificus and Clostridium bifermentans in a patient with subclinical liver disease is described. The patient appeared to recover from the infection initially after antibiotic therapy but finally succumbed to rapidly developing hepatic failure. Postmortem examination revealed hemochromatosis. The pathogenesis of the polymicrobial septicemia and hepatic failure is discussed in the light of the published literature.