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Literature DB >> 321158

A defect of the alternative pathway of complement.

Abstract

The sera of patients defective at opsonization for yeast phagocytosis fix haemolytic complement poorly following incubation with the alternative pathway complement activators, inulin and bacterial endotoxin. This suggests that the defect lies early in the alternative pathway of complement.

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Year: 1977 PMID： 321158 PMCID： PMC1540913

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

3 in total

1. The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena.

Authors: L PILLEMER; L BLUM; I H LEPOW; O A ROSS; E W TODD; A C WARDLAW
Journal: Science Date: 1954-08-20 Impact factor: 47.728

2. A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5).

Authors: M E Miller; U R Nilsson
Journal: N Engl J Med Date: 1970-02-12 Impact factor: 91.245

3. Defective opsonization. A common immunity deficiency.

Authors: J F Soothill; B A Harvey
Journal: Arch Dis Child Date: 1976-02 Impact factor: 3.791

3 in total

18 in total

1. Paediatric Research Society. Plymouth, 15 and 16 September 1978: Abstracts.

Authors:
Journal: Arch Dis Child Date: 1979-02 Impact factor: 3.791

2. Suboptimal C3b/C3bi deposition and defective yeast opsonization. I. Evidence for the absence of essential co-factor activity.

Authors: M W Turner; N D Seymour; M D Kazatchkine; J F Mowbray
Journal: Clin Exp Immunol Date: 1985-11 Impact factor: 4.330

3. A new semiquantitative radiometric opsonin assay. Selective measurement of opsonizing capacity of the alternative pathway.

Authors: M Yamamura; H Valdimarsson
Journal: Immunology Date: 1978-04 Impact factor: 7.397

A defect of the alternative pathway of complement.

1. The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena.

2. A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5).

3. Defective opsonization. A common immunity deficiency.

1. Paediatric Research Society. Plymouth, 15 and 16 September 1978: Abstracts.

2. Suboptimal C3b/C3bi deposition and defective yeast opsonization. I. Evidence for the absence of essential co-factor activity.

3. A new semiquantitative radiometric opsonin assay. Selective measurement of opsonizing capacity of the alternative pathway.

4. Impaired opsonization by serum from patients with chronic liver disease.

5. Polymorphonuclear neutrophil iodination response as an estimate of defective yeast opsonization.

6. Defective yeast opsonization and C2 deficiency in atopic patients.

7. Yeast opsonization in newborn infants and its relationship to parental atopy.

8. Defective yeast opsonisation and functional deficiency of complement in sickle cell disease.

9. A common congenital immunodeficiency predisposing to infection and atopy in infancy.

10. Defective opsonisation and complement deficiency in serum from patients with fulminant hepatic failure.