Literature DB >> 32114494

Flecainide toxicity: a presentation to the emergency department with literature review.

Rashpal Ghataoura1, Shashank Patil2.   

Abstract

Flecainide toxicity can result in increased cardiovascular instability which can significantly alter patient outcome if not recognised early. In this case report, the management of a 68-year-old woman who took an unintentional overdose of flecainide is detailed. We look at the management she received in the emergency department and her successful recovery and follow-up since the admission. In addition, the case report outlines the ECG changes that are most commonly documented in flecainide overdose and reviews the frequently used treatment methods for the overdose as summarised in current literature. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  drugs and medicines; emergency medicine; poisoning; resuscitation

Mesh:

Substances:

Year:  2020        PMID: 32114494      PMCID: PMC7050315          DOI: 10.1136/bcr-2019-232691

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  14 in total

1.  Brugada-type ECG pattern and extreme QRS complex widening with propafenone overdose.

Authors:  Can Hasdemir; Murat Olukman; Cem Ulucan; Dan M Roden
Journal:  J Cardiovasc Electrophysiol       Date:  2006-05

2.  Flecainide overdose causing a Brugada-type pattern on electrocardiogram in a previously well patient.

Authors:  Sanooj Soni; Sandeep Gandhi
Journal:  Am J Emerg Med       Date:  2009-03       Impact factor: 2.469

3.  Flecainide toxicity--treatment with intravenous fat emulsion and extra corporeal life support.

Authors:  Senthil K Sivalingam; Vijay T Gadiraju; Mini V Hariharan; Auras R Atreya; Joseph E Flack; Hany Aziz
Journal:  Acute Card Care       Date:  2013-11-07

4.  Use of intravenous lipid 20% emulsion for the treatment of a voluntary intoxication of flecainide with refractory shock.

Authors:  Pierre Etienne Moussot; Fouad Marhar; Vincent Minville; Baptiste Vallé; Emilie Dehours; Vincent Bounes; Jean-Louis Ducassé
Journal:  Clin Toxicol (Phila)       Date:  2011-07       Impact factor: 4.467

5.  Clinical course and outcome in class IC antiarrhythmic overdose.

Authors:  C Köppel; U Oberdisse; G Heinemeyer
Journal:  J Toxicol Clin Toxicol       Date:  1990

6.  Successful extracorporeal life support in a case of severe flecainide intoxication.

Authors:  G M Auzinger; C D Scheinkestel
Journal:  Crit Care Med       Date:  2001-04       Impact factor: 7.598

7.  Amiodarone used in successful resuscitation after near-fatal flecainide overdose.

Authors:  A Siegers; P N Board
Journal:  Resuscitation       Date:  2002-04       Impact factor: 5.262

Review 8.  Brugada syndrome: from cell to bedside.

Authors:  Charles Antzelevitch; Pedro Brugada; Josep Brugada; Ramon Brugada
Journal:  Curr Probl Cardiol       Date:  2005-01       Impact factor: 5.200

Review 9.  Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies.

Authors:  Chloé Jamaty; Benoit Bailey; Alexandre Larocque; Eric Notebaert; Karine Sanogo; Jean-Marc Chauny
Journal:  Clin Toxicol (Phila)       Date:  2010-01       Impact factor: 4.467

10.  Determining the optimal dose of intravenous fat emulsion for the treatment of severe verapamil toxicity in a rodent model.

Authors:  Eric Perez; Theodore C Bania; Kamal Medlej; Jason Chu
Journal:  Acad Emerg Med       Date:  2008-10-25       Impact factor: 3.451

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  2 in total

1.  Flecainide toxicity associated with the use of goji berries: a case report.

Authors:  Carlos E Guzmán; Carla Gabriela Guzmán-Moreno; José Luis Assad-Morell; Edgar Francisco Carrizales-Sepúlveda
Journal:  Eur Heart J Case Rep       Date:  2021-06-01

2.  A Case Report of Flecainide Toxicity With Review of Literature.

Authors:  Pratik Khatiwada; Lindsey Clark; Arjun Khunger; Bhimesh B Rijal; Jody Ritter
Journal:  Cureus       Date:  2022-02-15
  2 in total

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