| Literature DB >> 32114099 |
Abstract
We recently demonstrated that NMDA receptors (NMDARs) are capable of ion-flux independent signaling through conformational change in the NMDAR intracellular domain resulting in long-term depression of synaptic transmission (LTD). Here we show that PSD-95 overexpression blocks agonist induced conformational movement in the NMDAR intracellular domain as well as LTD that is NMDAR-dependent and ion-flux independent. Interestingly, previous studies indicate that overexpressed PSD-95 does not block NMDAR-dependent LTD. These data support a model where ion-flux independent LTD is predominant in young animals, which have synapses with low amounts of PSD-95, whereas only ion flux dependent LTD occurs at more mature synapses, which have more PSD-95 that would block ion-flux independent LTD. These results may reconcile different findings regarding ion-flux independent LTD.Entities:
Keywords: MAGUK; NMDA receptor; conformational movement; long-term depression; metabotropic signaling; post-synaptic density protein 95
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Year: 2020 PMID： 32114099 PMCID： PMC7483149 DOI： 10.1016/j.neuroscience.2020.02.020
Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590