Yanfeng Xi1, Chen Xu2, Yiqiang Liu3, Xiaochu Yan4, Chuansheng Huang5, Yueping Liu6, Jinhong Mei7, Zhe Wang8, Bin Liu9, Xiaoming Li10, Wencai Li11, Jianyun Lan12, Peng Gao13, Jifeng Wu14, Jianming Zheng15, Yingyong Hou16. 1. Department of Pathology, Shanxi Cancer Hospital, Taiyuan, China. 2. Department of Pathology, Zhongshan Hospital; Department of Pathology, School of Basic Sciences & Zhongshan Hospital, Fudan University, Shanghai, China. 3. Department of Pathology, Beijing Cancer Hospital, Beijing, China. 4. Department of Pathology, The First Hospital Affiliated to AMU (Southwest Hospital), Chongqing, China. 5. Department of Pathology, Jiangxi Cancer Hospital, Nanchang, China. 6. Department of Pathology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China. 7. Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, China. 8. Department of Pathology, Xijing Hospital, Air Force Medical University (The Fourth Military Medical University), Xi'an, China. 9. Department of Pathology, Lanzhou General Hospital of People's Liberation Army, Lanzhou, China. 10. Department of Pathology, Lanzhou University Second Hospital, Lanzhou, China. 11. Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 12. Department of Pathology, Yancheng City No.1 People's Hospital, Yancheng, China. 13. Department of Pathology, Qilu Hospital of Shandong University, Jinan, China. 14. Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. 15. Department of Pathology, Changhai Hospital, Naval Medical University, Shanghai, China. 16. Department of Pathology, Zhongshan Hospital; Department of Pathology, School of Basic Sciences & Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: houyingyong@aliyun.com.
Abstract
AIMS: The aim of this study was to explore HER2 status and characteristics in biopsy specimens of gastric cancer (GC) in Chinese population. METHODS AND RESULTS: A total of 27,787 biopsy specimens of GC from 103 hospitals were obtained. Immunohistochemistry (IHC) staining of HER2 was performed. Overall HER2 IHC positive rate was 11.2 %. HER2 positive rate elevated with the increase of age in total patients and both genders. The rates were 7.1 %, 8.1 %, 9.0 %, 10.9 %, 11.8 %, 12.6 %, and 12.1 % when patient age was ≤30, 31-40, 41-50, 51-60, 61-70, 71-80, and >80, respectively (P < 0.001). In male, the rates were 6.5 %, 8.4 %, 9.6 %, 11.5 %, 12.4 %, 13.3 %, and 12.1 % (P < 0.001). In female, the rates were 7.4 %, 7.9 %, 8.0 %, 9.0 %, 9.6 %, 10.6 %, and 11.9 % (P = 0.128). The changes in male were more dramatic than in female (P < 0.001). Furthermore, the proportion of the intestinal type GCs increased with age in total patients and both genders (P < 0.001), and in male the changes were more dramatic (P < 0.001). While the proportion of the diffuse type showed the opposite tendency to that of the intestinal type (P < 0.001). HER2 IHC positive rate showed a positive correlation with the proportion of the intestinal type (r=0.986, P < 0.001), and a negative correlation with the proportion of the diffuse type (r=0.984, P < 0.001). CONCLUSIONS: The HER2 IHC positive rate showed age variation in biopsy specimens of GC. In male the variation was more dramatic than in female. The variation of HER2 positive rate can be attributed to the age variation of the Lauren subtypes.
AIMS: The aim of this study was to explore HER2 status and characteristics in biopsy specimens of gastric cancer (GC) in Chinese population. METHODS AND RESULTS: A total of 27,787 biopsy specimens of GC from 103 hospitals were obtained. Immunohistochemistry (IHC) staining of HER2 was performed. Overall HER2 IHC positive rate was 11.2 %. HER2 positive rate elevated with the increase of age in total patients and both genders. The rates were 7.1 %, 8.1 %, 9.0 %, 10.9 %, 11.8 %, 12.6 %, and 12.1 % when patient age was ≤30, 31-40, 41-50, 51-60, 61-70, 71-80, and >80, respectively (P < 0.001). In male, the rates were 6.5 %, 8.4 %, 9.6 %, 11.5 %, 12.4 %, 13.3 %, and 12.1 % (P < 0.001). In female, the rates were 7.4 %, 7.9 %, 8.0 %, 9.0 %, 9.6 %, 10.6 %, and 11.9 % (P = 0.128). The changes in male were more dramatic than in female (P < 0.001). Furthermore, the proportion of the intestinal type GCs increased with age in total patients and both genders (P < 0.001), and in male the changes were more dramatic (P < 0.001). While the proportion of the diffuse type showed the opposite tendency to that of the intestinal type (P < 0.001). HER2 IHC positive rate showed a positive correlation with the proportion of the intestinal type (r=0.986, P < 0.001), and a negative correlation with the proportion of the diffuse type (r=0.984, P < 0.001). CONCLUSIONS: The HER2 IHC positive rate showed age variation in biopsy specimens of GC. In male the variation was more dramatic than in female. The variation of HER2 positive rate can be attributed to the age variation of the Lauren subtypes.