Efsun Tanacan1, Nilgun Atakan2. 1. Department of Dermatology and Veneorology, Ufuk University School of Medicine, Ankara, Turkey. Electronic address: efsunkln@yahoo.com. 2. Department of Dermatology and Veneorology, Hacettepe University Hospital, Ankara, Turkey.
Abstract
BACKGROUND/ OBJECTIVES: To investigate the association between vitiligo and metabolic syndrome (MetS). METHODS: A prospective cross-sectional study was conducted between 2014 and 2016. Study (n=155) and control groups (n=155) were evaluated for MetS according to National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and The International Diabetes Federation criteria. Study group was divided into three groups according to their vitiligo area severity index and vitiligo disease activity score values (Group 1: 6.89 for VASI score, Group A: -1-0, Group B: 1-2 and Group C: 3-4 for vitiligo disease activity score respectively). MetS rates according to both criteria were compared between the vitiligo disease activity score and vitiligo area severity index groups. RESULTS: MetS rates were 37.4% and 40% in the study group and 19.4% and 26.5% in the control group according to NCEP-ATPIII and IDF criteria, respectively (p<001 and p=0.011). MetS was more frequent in vitiligo area severity index Groups 2 and 3 compared to vitiligo area severity index Group 1, and in vitiligo disease activity score Group C compared to vitiligo disease activity score Groups A and B. STUDY LIMITATIONS: Single center experience, absence of more specific oxidative-stress markers and lack of long-term follow-up of the patients. CONCLUSIONS: Frequency of MetS was higher in patients with non-segmental vitiligo and the rate was higher in active/severe form of the disease.
BACKGROUND/ OBJECTIVES: To investigate the association between vitiligo and metabolic syndrome (MetS). METHODS: A prospective cross-sectional study was conducted between 2014 and 2016. Study (n=155) and control groups (n=155) were evaluated for MetS according to National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and The International Diabetes Federation criteria. Study group was divided into three groups according to their vitiligo area severity index and vitiligo disease activity score values (Group 1: 6.89 for VASI score, Group A: -1-0, Group B: 1-2 and Group C: 3-4 for vitiligo disease activity score respectively). MetS rates according to both criteria were compared between the vitiligo disease activity score and vitiligo area severity index groups. RESULTS:MetS rates were 37.4% and 40% in the study group and 19.4% and 26.5% in the control group according to NCEP-ATPIII and IDF criteria, respectively (p<001 and p=0.011). MetS was more frequent in vitiligo area severity index Groups 2 and 3 compared to vitiligo area severity index Group 1, and in vitiligo disease activity score Group C compared to vitiligo disease activity score Groups A and B. STUDY LIMITATIONS: Single center experience, absence of more specific oxidative-stress markers and lack of long-term follow-up of the patients. CONCLUSIONS: Frequency of MetS was higher in patients with non-segmental vitiligo and the rate was higher in active/severe form of the disease.
Authors: Azza Gaber Antar Farag; Eman A E Badr; Asmaa El-Shafey Soliman El-Shafey; Mustafa Elsayed Elshaib Journal: An Bras Dermatol Date: 2021-11-25 Impact factor: 1.896
Authors: Elias de França; Ronaldo V T Dos Santos; Liliana C Baptista; Marco A R Da Silva; André R Fukushima; Vinícius B Hirota; Raul A Martins; Erico C Caperuto Journal: Front Physiol Date: 2022-03-10 Impact factor: 4.566