Literature DB >> 3211366

The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma.

A C Sandberg1, C Engberg, M Lake, H von Holst, V R Sara.   

Abstract

Expression of insulin-like growth factor I (IGF-I) and insulin-like growth factor II (IGF-II) genes in the human brain and in glioma was studied by slot blot and Northern analysis following hybridization of IGF-I and IGF-II cDNA probes to isolated mRNA. In the fetal brain there were major IGF-I transcripts of 7.5 and 4.4 kilobases (kb) and one major IGF-II transcript of 6.0 kb. IGF-II mRNA was less abundant in the adult brain, with IGF-II mRNA being scarcely detectable. All glioma tissue examined displayed a marked enhancement of both IGF-I and IGF-II gene expression when compared to normal brain. IGF-I transcripts of 4.4 and 2.2-1.8 kb were identified. Similar to fetal brain a major IGF-II transcript of 6.0 kb was found in the glioblastoma examined.

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Year:  1988        PMID： 3211366     DOI： 10.1016/0304-3940(88)90022-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  25 in total

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Review 2.  Insulin-like growth factors in central nervous system tumors.

Authors:  R P Glick; T Lichtor; T G Unterman
Journal:  J Neurooncol       Date:  1997-12       Impact factor: 4.130

Review 3.  The IGF/IGFBP system in CNS malignancy.

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Journal:  Mol Pathol       Date:  2001-08

4.  Human glioma cells transformed by IGF-I triple helix technology show immune and apoptotic characteristics determining cell selection for gene therapy of glioblastoma.

Authors:  A Ly; H T Duc; M Kalamarides; L A Trojan; Y Pan; A Shevelev; J C François; T Noël; A Kane; D Henin; D D Anthony; J Trojan
Journal:  Mol Pathol       Date:  2001-08

Review 5.  The many faces of insulin-like peptide signalling in the brain.

Authors:  Ana M Fernandez; Ignacio Torres-Alemán
Journal:  Nat Rev Neurosci       Date:  2012-03-20       Impact factor: 34.870

6.  Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2.

Authors:  Hemant K Bid; Jun Zhan; Doris A Phelps; Raushan T Kurmasheva; Peter J Houghton
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7.  A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors.

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8.  Insulin-like growth factor (IGF)-I, -II and IGF-binding proteins in the cyst fluid of a patient with astrocytoma.

Authors:  W Zumkeller; M Sääf; T Rähn
Journal:  Childs Nerv Syst       Date:  1993-04       Impact factor: 1.475

9.  The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma.

Authors:  Raushan T Kurmasheva; Lorina Dudkin; Catherine Billups; Larisa V Debelenko; Christopher L Morton; Peter J Houghton
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10.  GFAP expression in the subcutaneous tumors of immature glial cell line (HITS glioma) derived from ENU-induced rat glioma.

Authors:  Y Ikeno; I Shimokawa; Y Higami; T Ikeda
Journal:  J Neurooncol       Date:  1993-09       Impact factor: 4.130
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