Ayşe İdil Çakmak1, Eray Atalay2, Saadet Gültekin Irgat3, Zülfiye Köktaş4, Nilgün Yıldırım4. 1. Department of Ophthalmology, Hatay Mustafa Kemal University Faculty of Medicine, Hatay, Turkey. 2. Department of Ophthalmology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey. eatalay@ogu.edu.tr. 3. Department of Ophthalmology, Kütahya Health Sciences University School of Medicine, Kütahya, Turkey. 4. Department of Ophthalmology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey.
Abstract
PURPOSE: To investigate the associations between mean ocular perfusion pressure (MOPP) and several variables including body mass index (BMI), comorbid medical conditions and various ocular parameters in a population-based sample. STUDY DESIGN: Cross-sectional. METHODS: Data of 2091 healthy participants from a previous population based cross-sectional study were reviewed. Inclusion criteria were adults ≥40 years of age who were screened on-site for glaucoma. Data on medical history, height, weight, systolic and diastolic blood pressures (SBP and DBP, respectively) were obtained. A basic ocular examination was performed which included intraocular pressure (Tono-Pen XL, Reichert Technologies) and central corneal thickness (Pacline pachymetry;) measurement, slit-lamp examination and non-mydriatic optic disc photography (nonmydα fundus camera, Kowa). MOPP was calculated using the formula [2/3 x (DBP + 1/3(SBP-DBP)]-IOP and low MOPP was defined as MOPP ≤45 mmHg. RESULTS: Mean age of the subjects was 63.04 ± 9.7 years (range: 44 and 99 years) and the majority were women (74.1%, n = 1549). Mean MOPP values in normal weight (BMI < 25), overweight (BMI = 25-29.9) and in obese individuals were 46.9 ± 9.0 mmHg, 48.6 ± 9.2 mmHg and 50.7 ± 10.0 mmHg, respectively (p < 0.001, in all pairwise comparisons). In the multivariable logistic regression analysis, migraine and IOP elevation (per 1 mmHg increment) were significantly associated with a low MOPP (OR: 2.10 and 1.22, p = 0.008 and < 0.001, respectively). On the other hand, risk of low MOPP was reduced in subjects with hypertension, and with increasing age (per 1-year increment) and BMI (per 1-unit increment) (OR: 0.15, 0.97, and 0.95, respectively, and p < 0.001 for all). CONCLUSION: Migraine and elevated IOP increase the risk of low MOPP and this may have a causal relationship with impaired optic nerve head blood flow.
PURPOSE: To investigate the associations between mean ocular perfusion pressure (MOPP) and several variables including body mass index (BMI), comorbid medical conditions and various ocular parameters in a population-based sample. STUDY DESIGN: Cross-sectional. METHODS: Data of 2091 healthy participants from a previous population based cross-sectional study were reviewed. Inclusion criteria were adults ≥40 years of age who were screened on-site for glaucoma. Data on medical history, height, weight, systolic and diastolic blood pressures (SBP and DBP, respectively) were obtained. A basic ocular examination was performed which included intraocular pressure (Tono-Pen XL, Reichert Technologies) and central corneal thickness (Pacline pachymetry;) measurement, slit-lamp examination and non-mydriatic optic disc photography (nonmydα fundus camera, Kowa). MOPP was calculated using the formula [2/3 x (DBP + 1/3(SBP-DBP)]-IOP and low MOPP was defined as MOPP ≤45 mmHg. RESULTS: Mean age of the subjects was 63.04 ± 9.7 years (range: 44 and 99 years) and the majority were women (74.1%, n = 1549). Mean MOPP values in normal weight (BMI < 25), overweight (BMI = 25-29.9) and in obese individuals were 46.9 ± 9.0 mmHg, 48.6 ± 9.2 mmHg and 50.7 ± 10.0 mmHg, respectively (p < 0.001, in all pairwise comparisons). In the multivariable logistic regression analysis, migraine and IOP elevation (per 1 mmHg increment) were significantly associated with a low MOPP (OR: 2.10 and 1.22, p = 0.008 and < 0.001, respectively). On the other hand, risk of low MOPP was reduced in subjects with hypertension, and with increasing age (per 1-year increment) and BMI (per 1-unit increment) (OR: 0.15, 0.97, and 0.95, respectively, and p < 0.001 for all). CONCLUSION: Migraine and elevated IOP increase the risk of low MOPP and this may have a causal relationship with impaired optic nerve head blood flow.