Lígia Moriguchi Watanabe1, Lívia Fernandes de Lima2, Rafael Ferraz-Bannitz2, Daniela Takaara2, Beatriz Coimbra Romano3, Telma Maria Braga Costa3, Maria Cristina Foss de Freitas2, Ana Carolina Bueno4, Fernando Barbosa Júnior5, Anderson Marliere Navarro6. 1. Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo - FMRP/USP, Brazil. Electronic address: ligia_watanabe@usp.br. 2. Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo - FMRP/USP, Brazil. 3. Department of Nutrition, University of Ribeirão Preto - UNAERP, Brazil. 4. Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo - FMRP/USP, Brazil. 5. Department of Clinical and Toxicological Analyses and Bromatology, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - FCFRP/USP, Brazil. 6. Department of Health Sciences, Division of Nutrition and Metabolism, Ribeirão Preto Medical School, University of São Paulo - FMRP/USP, Brazil.
Abstract
BACKGROUND & AIMS: Although the mechanisms by which statins promote muscle disorders remain unclear, supplementation with dietary antioxidants may mitigate statins' side effects. This study aimed to investigate whether the consumption of Brazil nuts modulates serum creatine kinase (CK) activity in patients regularly using statins. METHODS: The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients in regular use of statins were divided according to CK activity levels (G1: increased or G2: normal) and received one unit of Brazil nut daily for 3 months. Body composition, blood selenium (Se) concentrations, erythrocyte glutathione peroxidase (GPX) activity, oxidative stress parameters, and CK activity were evaluated before and after supplementation. RESULTS: In both groups, supplementation with one Brazil nut daily for 3 months contributed to achieve decreased levels of CK activity in serum, with positive changes in plasma and erythrocyte Se concentrations (p < 0.0001), and increased levels of GPX activity. Among the parameters related to curbing of oxidative stress, we observed reduced levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in both groups after supplementation. We also found a moderately negative association between CK and GPX activity (r = -41; p < 0.02). Expression of selenoproteins GPX1, SELENOP, and SELENON after Brazil nut supplementation was unchanged. CONCLUSION: Brazil nut consumption enhanced the control of CK activity by improving oxidative stress biomarkers in patients using statins but did not modulate mRNA expression of selenoproteins.
BACKGROUND & AIMS: Although the mechanisms by which statins promote muscle disorders remain unclear, supplementation with dietary antioxidants may mitigate statins' side effects. This study aimed to investigate whether the consumption of Brazil nuts modulates serum creatine kinase (CK) activity in patients regularly using statins. METHODS: The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients in regular use of statins were divided according to CK activity levels (G1: increased or G2: normal) and received one unit of Brazil nut daily for 3 months. Body composition, blood selenium (Se) concentrations, erythrocyte glutathione peroxidase (GPX) activity, oxidative stress parameters, and CK activity were evaluated before and after supplementation. RESULTS: In both groups, supplementation with one Brazil nut daily for 3 months contributed to achieve decreased levels of CK activity in serum, with positive changes in plasma and erythrocyte Se concentrations (p < 0.0001), and increased levels of GPX activity. Among the parameters related to curbing of oxidative stress, we observed reduced levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in both groups after supplementation. We also found a moderately negative association between CK and GPX activity (r = -41; p < 0.02). Expression of selenoproteins GPX1, SELENOP, and SELENON after Brazil nut supplementation was unchanged. CONCLUSION:Brazil nut consumption enhanced the control of CK activity by improving oxidative stress biomarkers in patients using statins but did not modulate mRNA expression of selenoproteins.
Authors: Ligia M Watanabe; Ann C Hashimoto; Daniel J Torres; Naghum Alfulaij; Rafael Peres; Razvan Sultana; Alika K Maunakea; Marla J Berry; Lucia A Seale Journal: Mol Cell Endocrinol Date: 2021-05-27 Impact factor: 4.369
Authors: Leila Khalili; Thoraya Mohamed Elhassan A-Elgadir; Ayaz Khurram Mallick; Hesham Ali El Enshasy; R Z Sayyed Journal: Front Nutr Date: 2022-03-29